Evidence supporting the use of: Alpha lipoic acid
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) is an antioxidant that has been investigated for its potential to reduce fatigue, particularly in certain medical conditions. The scientific evidence supporting its use for fatigue is limited and mixed. Some small clinical studies have explored ALA supplementation in patients with conditions like multiple sclerosis (MS), diabetes, or chronic fatigue syndrome, as oxidative stress is thought to contribute to fatigue in these populations. For instance, a few trials in MS patients showed a modest reduction in fatigue severity when taking ALA compared to placebo, likely due to its neuroprotective and anti-inflammatory properties. However, these studies often have small sample sizes and short durations, making it difficult to draw firm conclusions.

There is little evidence that ALA supplementation reduces fatigue in otherwise healthy individuals. Most of the supportive data come from populations with underlying oxidative stress or mitochondrial dysfunction. Systematic reviews and meta-analyses have not conclusively demonstrated a significant benefit of ALA for general fatigue. As such, while there is some scientific rationale and preliminary evidence for using ALA in specific cases of fatigue, especially where oxidative stress is implicated, the overall quality and quantity of evidence is low. More robust, large-scale clinical trials are needed to establish its efficacy for this purpose.

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Other ingredients used for Fatigue

Acai berry
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
adrenal cortex
Alfalfa
Alpha D-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
apple
arjun tree
ashwagandha
asparagus
aspartic acid
astaxanthin
astragalus
Waterhyssop
barley
beet
bergamot
berry flavor
beta-alanine
betel
Bifidobacterium breve
black cumin
black garlic
sesame
black tea
bonito peptide
Indian frankincense
bovine heart
bovine kidney
bovine liver
bovine spleen
branched-chain amino acids
rice
bupleurum falcatum
burdock
caffeine
cat's claw
caterpillar mushroom
chaga mushroom
chen pi
chia seed
Chinese salvia root
chlorella
chokeberry
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
damiana
DHEA (dehydroepiandrosterone)
eleuthero
fennel
fenugreek
fish protein
folate
fruit and vegetable blend (proprietary)
fu ling
ginseng
gooseberry
gotu kola
Greek mountain tea
green tea
guarana
guayusa
hibiscus
Indian tinospora
iron
knotweed
jujube
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-alanyl-L-glutamine
l-carnitine
L-cysteine
L-glycine
L-leucine
L-ornithine
L-taurine
l-tyrosine
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lactiplantibacillus plantarum
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lion's mane
liquid liver fractions
lychee
maca
magnesium
maitake mushroom
malic acid
maltodextrin
mango
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Marine lipid
Matcha
Melatonin
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Muira puama
Acetyl-L-Tyrosine
Nettle
nicotinamide riboside
spruce
oat
okra
omega-3 fatty acids
ophiopogon root
orange
ornithine alpha-ketoglutarate
oyster mushroom
pantothenic acid (vitamin B5)
parsley
Peppermint
phellodendron amurense
plum fruit
pollen
polygala root
pomegranate
potassium
prebiotic blend (proprietary)
protein
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quail egg
quercetin
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relora® (proprietary)
Rhodiola
riboflavin (vitamin B2)
rosemary
scrophularia root
shiitake mushroom
black ginger
spinach
spirulina
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ubiquinol
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velvet bean
vitamin B
vitamin B12
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vitamin C
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seaweed
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wheat grass
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whole adrenal glandular
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β-nicotinamide mononucleotide (NMN)
sarsaparilla
suma
jiaogulan
oryza
gastrodia
cardamom
atractylodes
nut grass
punarnava
smilax
Tinospora cordifolia
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bee pollen
peony
lingzhi
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root tuber
silk tree
haliotis
amber
cistanche
dioscorea
dodder
ganoderma
lotus seed
Morinda
electrolytes blend (proprietary)
dulse leaf
royal jelly
trace minerals
anemarrhena asphodeloides
purslane
fulvic acid
aster root
Yerba mate
wheat germ
noni
Wood betony
biota seed
nopal
goji berry
amaranth
millet seed
Algae
cocoa
thyroid substance
ashitaba
soursop
sea salt
DMPX
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Aralia
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arjuna
Akebia
apple cider vinegar
Alpha polylactate
antler
arginine creatine
Ardisia
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Achyranthes
anamu
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alpha-lipoic acid
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chard
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date
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horse gram
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horny goat weed
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ketone salts
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macaenes
NADH
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oolong tea
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ornithine L-aspartic acid
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pyrroloquinoline quinone
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ribose
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Xanthine
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Xanthone
Yuzu
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Zucchini
Zapilopatle Bean
Zedoary

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