Evidence supporting the use of: Ashwagandha
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ashwagandha (Withania somnifera), a prominent herb in Ayurvedic medicine, has a long tradition of use for enhancing vitality and reducing fatigue. Historically, it has been classified as a “rasayana,” or rejuvenating tonic, believed to support overall energy and resilience. In recent years, scientific interest has grown regarding its adaptogenic properties—its purported ability to help the body cope with stress and fatigue.

Multiple randomized, placebo-controlled trials have investigated ashwagandha’s effects on fatigue, particularly in the context of chronic stress and physical exertion. For example, studies in individuals with stress or anxiety have reported reductions in self-reported fatigue and improvements in energy levels with ashwagandha supplementation (typically 300-600 mg/day of root extract). Some research has also shown benefits in patients with chronic fatigue syndrome and in healthy adults exposed to strenuous physical activity, where ashwagandha improved measures of physical endurance and reduced perceived fatigue.

The proposed mechanisms include modulation of the hypothalamic-pituitary-adrenal (HPA) axis, reduction of cortisol levels, and enhancement of mitochondrial function. However, while data are promising, most studies are small and of short duration; larger, well-designed clinical trials are needed for definitive conclusions. Overall, both traditional use and emerging scientific evidence support ashwagandha’s potential to alleviate fatigue, but the evidence quality is moderate at present.

More about ashwagandha
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Other ingredients used for Fatigue

Acai berry
Acetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
adrenal cortex
Alfalfa
Alpha D-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
apple
arjun tree
ashwagandha
asparagus
aspartic acid
astaxanthin
astragalus
Waterhyssop
barley
beet
bergamot
berry flavor
beta-alanine
betel
Bifidobacterium breve
black cumin
black garlic
sesame
black tea
bonito peptide
Indian frankincense
bovine heart
bovine kidney
bovine liver
bovine spleen
branched-chain amino acids
rice
bupleurum falcatum
burdock
caffeine
cat's claw
caterpillar mushroom
chaga mushroom
chen pi
chia seed
Chinese salvia root
chlorella
chokeberry
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
damiana
DHEA (dehydroepiandrosterone)
eleuthero
fennel
fenugreek
fish protein
folate
fruit and vegetable blend (proprietary)
fu ling
ginseng
gooseberry
gotu kola
Greek mountain tea
green tea
guarana
guayusa
hibiscus
Indian tinospora
iron
knotweed
jujube
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-alanyl-L-glutamine
l-carnitine
L-cysteine
L-glycine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
lactiplantibacillus plantarum
Lactoferrin
Lentinula edodes mycelia
lion's mane
liquid liver fractions
lychee
maca
magnesium
maitake mushroom
malic acid
maltodextrin
mango
mangosteen
Marine lipid
Matcha
Melatonin
Milk
Moringa
Muira puama
Acetyl-L-Tyrosine
Nettle
nicotinamide riboside
spruce
oat
okra
omega-3 fatty acids
ophiopogon root
orange
ornithine alpha-ketoglutarate
oyster mushroom
pantothenic acid (vitamin B5)
parsley
Peppermint
phellodendron amurense
plum fruit
pollen
polygala root
pomegranate
potassium
prebiotic blend (proprietary)
protein
prune
pyrroloquinoline disodium salt
quail egg
quercetin
quinoa
rehmannia glutinosa
reishi mushroom
relora® (proprietary)
Rhodiola
riboflavin (vitamin B2)
rosemary
scrophularia root
shiitake mushroom
black ginger
spinach
spirulina
Thiamin (vitamin B1)
Tongkat ali
Trimethylglycine (TMG)
Triphala
Almond fruit
Turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
velvet bean
vitamin B
vitamin B12
vitamin B6
vitamin C
vitamin D
seaweed
Watercress
Watermelon
wheat grass
Whey protein
Mulberry
whole adrenal glandular
Yeast
β-nicotinamide mononucleotide (NMN)
sarsaparilla
suma
jiaogulan
oryza
gastrodia
cardamom
atractylodes
nut grass
punarnava
smilax
Tinospora cordifolia
Rubia cordifolia
bee pollen
peony
lingzhi
Morus
root tuber
silk tree
haliotis
amber
cistanche
dioscorea
dodder
ganoderma
lotus seed
Morinda
electrolytes blend (proprietary)
dulse leaf
royal jelly
trace minerals
anemarrhena asphodeloides
purslane
fulvic acid
aster root
Yerba mate
wheat germ
noni
Wood betony
biota seed
nopal
goji berry
amaranth
millet seed
Algae
cocoa
thyroid substance
ashitaba
soursop
sea salt
DMPX
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
Aralia
avens
arjuna
Akebia
apple cider vinegar
Alpha polylactate
antler
arginine creatine
Ardisia
Angelica
Antrodia camphorata
Arginine malate
Arginine aspartate
Achyranthes
anamu
Autumn Olive
Albizia
Arginine orotate
AHCC
Aletris
Agarwood
American Liverleaf
alpha-lipoic acid
astragaloside
Armillaria mellea
Alpha lactalbumin
Areca
Adzuki bean
Agrimonia pilosa
Adenosine triphosphate (ATP)
Algal protein
arjunic acid
Adenophora
Allium tuberosum
Amor seco
Arisaema
atractylone
animal protein
betony
black seed
Broussonetia
beta-hydroxybutyrate
breadnut
Blepharis
beef
Beef liver
big quaking grass
bone marrow
baccosides
Basidiomycota
black gram
Bauhinia
brahmi
ba ji tian
black salt
borassus palm
Borassus aethiopum
bacteria
Blue-Green Alage
banana
baobab
BCAA
Bupleurum
bacoside
baicalin
Bassia scoparia
bignay
Boerhavia diffusa
bottle gourd
borneol
bird\'s nest
chia seed
cumin
Camellia sinensis
coconut
Centella triterpenes
Chinese silkvine
curry leaf
cowpea
California chia
Cinnamomum
Clary sage
cocarboxylase
Chinese mountain ant
cyanobacteria
catalpol
coriolus mushroom
Codonopsis
cactus
Cynomorium
Cyathula
Chinese fleeceflower
Chinese pond turtle
cereal grass
Chlorophytum
chuchuhuasi
Cyclanthera pedata
curcumen
Cymbopogon martini
Cyanotis vaga
Centella asiatica
coca
Coconut Water
chocolate
chard
Chinese Ligustrum berry
creatine
corktree
chanterelle
catuaba
C-phycocyanin
Chondracanthus chamissoi
chestnut
costus
Cereus
Carthamus
cola nut
Canscora
currant
Chondrus
DHEA
Dendrobium
deer root
dodeca-2E, 4E-dienoic acid isobutylamide
dragon fruit
durian
deer velvet
dong quai
dibenzo-alpha pyrones
dragonhead
devil\'s club
Dolichos
date
dulse
D-Ribose
dextrose
duckweed
Ephedra
eurycomanone
Erythropalum scandens
eriocitrin
Eupolyphaga sinensis
Erodium cicutarium
Euryale seed
ergothioneine
elk antler
emblicanin
Eurycoma Longifolia
ecdysteroids
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Euglena gracilis
ephedrine
European five-finger grass
European hornbeam
Embelia
Ecklonia
enokitake
folic acid
fenuside
flavin mononucleotide
fo-ti
furostanols
flat-stem milk-vetch
fish
fatty acids
fungus
Flemingia philippinensis
Foxtail millet
finger-leaf morning glory
Flammulina velutipes
guanidinoacetic acid
Ginsenosides
Gypenoside
gamma-glutamylcysteine
Gentianella alborosea
Glycosaponin
GMS-ribose
glucose
giant blazingstar
Glechoma hederacea
Glutathione
Guaranine
garden cress
Gerovital H3
hydroxymethylbutyrate
horse gram
Himalayan salt
Hygrophila
horny goat weed
Hemidesmus
hypsizygus marmoreus
Herb Robert
hijiki
Hempnettle
hericium mushroom
Himalaya berry
honeybush
Horsemint
isomaltulose
iridoids
Indian sarsparilla
iridoid glycosides
Ilex
icariin
Indian fagonia
Jaboticaba
Japanese kadsura
joe-pye
Jatoba
Kokilaksha
Kokam
Kukicha
kiwi
Kutkins
kola nut
ketone salts
ketosterones
Kefir
Kombucha
kucha tea
kuding tea
Kumquat
Lycium
lemon balm
lucuma
ligustilides
Legume protein
longan
Ligustrum
Lindera
lotus
Lycopodium
Leptadenia
little ironweed
Loranthus
Molasses
macamides
mandarin
maral root
Methylcobalamin
Massularia acuminata
mangiferin
Mung bean
Marjoram
Malay bush
malt
Milk Protein
Mistletoe
Methylxanthine
Mountain pride
Momordica
Mimosa
Methylliberine
Mate
Mushroom
Ming Dang Shen
macaenes
NADH
Nardostachys
Natsudaidai
Ophiopogon
Oroxylum indicum
Ornithine
Orchis latifolia
oxaloacetic acid
oolong tea
Onosma bracteatum
orchid
Osmanthus
ornithine L-aspartic acid
Oxindole alkaloids
Oxypregnane glycoside
Phosphocreatine
Puerain
pyrroloquinoline quinone
Phyllanthus
paraxanthine
Phytoecdysteroid
Phaeophyceae
Plankton
polysaccharides
polyporous mushroom
Pentacyclic triterpenoids
Propionyl-L-Carnitine
pyruvate
Pepper
Pleurotus eryngii
Pentatropis capensis
Pseudostellaria
Portulaca
Piper nigrum
Prickly Pear Cactus
Passionfruit
Polygonatum
Persimmon
paeoniflorin
Palatinose
Physalis angulata
Pycnogenol
Polygonum
Peptides
Quinoa Protein
rosavins
Rubus
Rosabin
Rhodymenia
rockweed
Rehmannia
Rubiaceae
Rhaponticum
Rooibos
Rubia yunnanensis
ribose
Rosa roxburghii
robusta coffee
Sichuan Lovage
Silkmoth
Sophora
Spanish Needle
Selaginella
Sete sangrias
Shark Liver Oil
Spikenard
Salvia
Sulbutiamine
Salidroside
Safed musli
Sarivan
Spantholobus
Spelt
Schisandrins
Sida cordifolia
Scabrous Gentian
Semecarpus anacardium
saponins
Sumac
Schizandrol A
Shataverins
Sweet Bay
Shilajit
Sword Bean
Sweet Orange alcohol
Terminalia
Tea
Trichilia catigua
Tejocote
Turtle Head
Trichopus zeylanicus
Theacrine
Teacrine
Tiger Nut
Trametes
Tamarind
Tremella
Uncaria
Vetiver
Vegetable Protein
Vine tea
Withanolides
White Tea
Wax Gourd
Wheat
Water Pepper
Wulinshen
Winter Begonia
Xanthine
Xanthophyll
Xylaria nigripes
Xanthone
Yuzu
Yerba buena
Yohimbine
Zucchini
Zapilopatle Bean
Zedoary

Other health conditions supported by ashwagandha

Addictions (drugs)
Addictions (general remedies for)
Adrenal Fatigue
Afterbirth Pain
Aging (prevention)
Alcoholism
Allergies (respiratory)
Alzheimer's Disease
Amenorrhea
Anemia
Angina
Anorexia
Anxiety
Anxiety Disorders
Appetite (deficient)
Anger (excessive)
Arthritis
Asthma
Athletic and Exercise Aids
Attention Deficit Disorder
Autoimmune Disorders
Backache
Bedwetting
Body Building
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cholesterol (high)
Chronic Obstructive Pulmonary Disorder
Circulation (poor)
Concentration (poor)
Depression
Diabetes
Digestion (poor)
Emotional Sensitivity
Endurance (lack of)
Energy (lack of)
Epilepsy
Erectile Dysfunction
Exercise
Fatigue
Fear (excessive)
Fibromyalgia Syndrome
Goiter
Grief and Sadness
Hair (graying)
Hair (loss or thinning)
Hair Care (general)
Headache (general)
Headache (tension)
Heart (weakness)
Hot Flashes
Hypertension
Hypothyroid
Hysteria
Infertility
Inflammation
Insomnia
Irritability
Leucorrhea
Lyme Disease
Memory and Brain Function
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Migraine
Miscarriage (prevention)
Mood Swings
Muscle Tone (lack of)
Nervous Exhaustion
Nervousness
Neurosis
Nightmares
Nocturnal Emission
Obsessive Compulsive Disorder
Osteoporosis
Pain (general remedies for)
Parkinson's Disease
Peripheral Neuropathy
Pets (supplements for)
PMS (general)
PMS Type C
PMS Type D
Post Partum Depression
Post Partum Weakness
Post Traumatic Stress Disorder
Premature Ejaculation
Prolapsed Uterus
Rheumatoid Arthritis
Sex Drive (low)
Sleep (restless and disturbed)
Stress
Syphilis
Tension
Testosterone (low)
Thinking (cloudy)
TMJ
Tremors
Triglycerides (high)
Tuberculosis
Vitiligo
Weight Gain
Weight Loss
Worry
Wounds and Sores