Evidence supporting the use of: Flavan-3-ols
For the health condition: Fatigue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavan-3-ols are a class of polyphenols found in foods like tea, cocoa, and certain fruits. There is emerging scientific interest in their potential benefits for fatigue, particularly in populations experiencing mild fatigue or reduced energy levels. Some clinical studies have examined the effects of flavan-3-ol-rich foods (such as cocoa or green tea) on subjective feelings of fatigue, physical performance, and cognitive function. The mechanisms proposed include improved endothelial function, enhanced blood flow, and antioxidant effects, which may contribute to reduced feelings of tiredness and better physical endurance.

However, the evidence base supporting flavan-3-ols specifically for treating or managing fatigue remains limited and somewhat inconsistent. Most studies are small, short-term, or conducted in specific populations (e.g., athletes or older adults). A few randomized controlled trials have shown modest improvements in fatigue scores or exercise tolerance after consumption of flavan-3-ol-rich products, but the effects are generally mild and not always statistically significant. Major health organizations do not currently endorse flavan-3-ols as a treatment for fatigue.

In summary, while there is some scientific interest and preliminary evidence suggesting a possible benefit of flavan-3-ols for fatigue, the overall evidence is weak to moderate, and further well-designed studies are needed to confirm these effects and establish clinical relevance.

More about flavan-3-ols
More about Fatigue

Other ingredients used for Fatigue

acai berry
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adenosine 5-triphosphate disodium (ATP)
adrenal cortex
alfalfa
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
apple
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barley
beet
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beta-alanine
betel
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black cumin
black garlic
sesame
black tea
bonito peptide
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bovine heart
bovine kidney
bovine liver
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branched-chain amino acids
rice
bupleurum falcatum
burdock
caffeine
cat's claw
caterpillar mushroom
chaga mushroom
chen pi
chia seed
Chinese salvia root
chlorella
chokeberry
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
coffee fruit
cordyceps
creatine monohydrate
turmeric
damiana
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folate
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green tea
guarana
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Products containing flavan-3-ols

We currently have no products on Vitabase that contain this ingredient.