Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-valine is one of the three branched-chain amino acids (BCAAs), along with leucine and isoleucine. Its use to support or treat fatigue is primarily based on its role in muscle metabolism and energy production, particularly in athletes and during prolonged physical activity. Some scientific studies suggest that BCAAs, including L-valine, can reduce exercise-induced fatigue by competing with tryptophan for transport across the blood-brain barrier, thereby reducing the synthesis of serotonin, a neurotransmitter associated with the perception of fatigue. However, the evidence is mixed and often limited by small sample sizes and methodological weaknesses. While some trials report modest improvements in perceived fatigue and exercise performance, others have found no significant benefit of valine or BCAA supplementation over placebo. There is little evidence to support the use of L-valine for chronic fatigue syndrome or fatigue unrelated to exercise. Overall, while there is a plausible biological mechanism and some supportive data, the scientific validation remains modest, and more robust, large-scale clinical trials are needed to establish efficacy. The rating of "2" reflects that while some scientific evidence exists, it is not strong or consistent enough to warrant broad recommendations for fatigue management outside of specific athletic contexts.

More about l-valine
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Other ingredients used for Fatigue

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