Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Trimethylglycine (TMG), also known as betaine, is a compound naturally found in beets, spinach, and other foods. TMG is best known as a methyl donor, involved in the methylation of homocysteine to methionine—a process important for cardiovascular and metabolic health. The rationale for using TMG to address fatigue comes from its biochemical role in supporting methylation and energy production. Some proponents argue that by improving methylation and reducing homocysteine levels, TMG may support cellular energy metabolism, potentially reducing feelings of fatigue. However, direct scientific evidence supporting TMG as a treatment for general fatigue in humans is limited. There are a few studies exploring TMG supplementation in the context of exercise performance, where TMG has shown modest improvements in measures like power output and endurance, but these effects are not robust or consistently linked to reduced subjective fatigue. Additionally, most research has focused on athletic populations, not individuals experiencing chronic or unexplained fatigue. There is little to no evidence from clinical trials supporting its use in chronic fatigue syndrome or medically unexplained fatigue. TMG is not widely referenced in traditional medicine systems for fatigue, either. Overall, the scientific evidence supporting TMG’s use for fatigue is weak, and current ratings would place it around 2 out of 5, indicating limited preliminary support but a need for more rigorous, targeted research.

More about trimethylglycine (TMG)
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Other ingredients used for Fatigue

Other health conditions supported by trimethylglycine (TMG)

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