Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha Methyl Tetradecylthioacetic Acid (also known as Tetradecylthioacetic acid or TTA) has been investigated in preclinical and limited clinical studies as a potential treatment for Fatty Liver Disease (hepatic steatosis). TTA is a synthetic fatty acid analogue that acts primarily as a pan-agonist of peroxisome proliferator-activated receptors (PPARs), particularly PPAR-α, which plays a role in lipid metabolism and fatty acid oxidation.

Animal studies have demonstrated that TTA can reduce hepatic lipid accumulation, improve insulin sensitivity, and decrease inflammation associated with non-alcoholic fatty liver disease (NAFLD). In rodent models, TTA supplementation led to reduced liver fat content and improved liver function markers.

Human data, however, are quite limited. A small pilot study in obese humans with type 2 diabetes (N = 10) found that TTA supplementation for 4 weeks lowered plasma triglycerides and improved some markers of lipid metabolism, but there was no significant change in liver fat content as measured by imaging. Other early-phase trials have focused on lipid profiles and markers of inflammation rather than direct measures of hepatic steatosis.

In summary, while there is experimental and early clinical evidence supporting a mechanistic role for TTA in lipid metabolism and fatty liver, the current clinical evidence is insufficient for strong recommendations. Its use is primarily supported by preclinical studies and limited clinical trials, and further well-controlled human studies are needed to establish efficacy and safety for fatty liver disease.

More about alpha Methyl Tetradecylthioacetic Acid
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akkermansia muciniphila
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alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
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artichoke
astaxanthin
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barberry
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bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
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chlorella
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choline
conjugated linoleic acid (CLA)
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diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
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fish oil
fish protein
flavonols
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ginger
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l-carnitine
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l-methionine
l-taurine
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marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
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phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
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resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
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vitamin C
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zinc
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punarnava
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Ampelopsin
Algal protein
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Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
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Betanin
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bile acid
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chlorogenic acid
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DL-Methionine
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D-Pinitol
Diosgenin
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epicatechin
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walnut
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Other health conditions supported by alpha Methyl Tetradecylthioacetic Acid

Cholesterol (high)
Fat Metabolism (poor)
Fatty Liver Disease
Metabolic Syndrome
Triglycerides (high)

Products containing alpha Methyl Tetradecylthioacetic Acid

We currently have no products on Vitabase that contain this ingredient.