Evidence supporting the use of: Ampelopsin
For the health condition: Fatty Liver Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Ampelopsin (also known as dihydromyricetin or DHM) is a flavonoid compound primarily derived from the plant Ampelopsis grossedentata. There is a growing body of preclinical scientific evidence suggesting that ampelopsin may have beneficial effects on fatty liver disease, particularly non-alcoholic fatty liver disease (NAFLD). Several animal studies have shown that ampelopsin can reduce liver fat accumulation, improve lipid metabolism, decrease inflammation, and attenuate oxidative stress in models of fatty liver disease. For example, research published in peer-reviewed journals between 2012 and 2023 has demonstrated that ampelopsin supplementation reduces hepatic steatosis and improves markers of liver function in mice fed high-fat diets.
The proposed mechanisms include the regulation of AMP-activated protein kinase (AMPK), improvement of insulin sensitivity, and modulation of inflammatory pathways. However, it is important to note that while these effects are promising, the majority of evidence comes from in vitro studies and animal models. There is a scarcity of high-quality human clinical trials directly investigating the efficacy of ampelopsin for the treatment or support of fatty liver disease. As such, while scientific interest is justified and early data are encouraging, the overall evidence level remains modest (rated 2/5), and more rigorous human studies are needed before ampelopsin can be recommended as a standard therapy for fatty liver disease.
Other ingredients used for Fatty Liver Disease
akkermansia muciniphilaalgal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
Camelina Oil
Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fiber
Rhubarb
walnut
Zucchini
Other health conditions supported by Ampelopsin
Aging (prevention)Alzheimer's Disease
Arthritis
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Cholesterol (high)
Diabetes
Fatty Liver Disease
Hypertension
Inflammation
Memory and Brain Function
Metabolic Syndrome
Osteoporosis
Rheumatoid Arthritis
Triglycerides (high)