Evidence supporting the use of: Artichoke
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Artichoke (Cynara scolymus) has been traditionally used for liver health in various cultures, but in recent years, its use for fatty liver disease (non-alcoholic fatty liver disease, NAFLD) has gained some scientific support. Several clinical studies and animal experiments have explored artichoke leaf extract’s effect on liver function and lipid metabolism. Key bioactive compounds in artichoke, such as cynarin, chlorogenic acid, and flavonoids, are believed to possess antioxidant, lipid-lowering, and hepatoprotective properties.

A number of randomized controlled trials (RCTs) have shown that supplementation with artichoke leaf extract can reduce liver enzyme levels (such as ALT and AST) and improve markers of lipid metabolism in patients with NAFLD. For example, a 2018 double-blind RCT published in "Phytotherapy Research" found significant reductions in liver enzymes and improvements in ultrasound-detected liver steatosis after 2 months of artichoke supplementation. Proposed mechanisms include enhancement of bile flow, reduction of oxidative stress, and modulation of lipid synthesis and breakdown.

However, limitations include small sample sizes, short durations, and heterogeneity in extract formulations. While the evidence is promising and provides a scientific rationale for artichoke’s use in fatty liver disease, it is not yet robust enough for unequivocal recommendation. More large-scale, long-term trials are needed to confirm efficacy and safety.

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