Evidence supporting the use of: Astragaloside
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astragaloside, a key bioactive saponin compound derived from Astragalus membranaceus, has been investigated in recent years for its potential role in managing fatty liver disease (non-alcoholic fatty liver disease, NAFLD). Preclinical studies in animal models and cell cultures have demonstrated that astragaloside may exert hepatoprotective effects by modulating lipid metabolism, reducing hepatic steatosis, attenuating oxidative stress, and inhibiting inflammatory pathways associated with NAFLD. For example, several studies have indicated that astragaloside IV can activate AMP-activated protein kinase (AMPK), thereby reducing lipid accumulation in liver cells, and suppress the expression of pro-inflammatory cytokines such as TNF-α and IL-6.

However, despite these promising laboratory findings, there is a lack of high-quality clinical trials in humans confirming the efficacy of astragaloside for fatty liver disease. Most available evidence is limited to animal studies and mechanistic research, with only preliminary or indirect evidence from small-scale human studies using Astragalus extracts (not isolated astragaloside). Consequently, while there is a scientific rationale and some experimental validation for its use, the overall quality and quantity of evidence supporting astragaloside as a treatment or supportive agent for fatty liver disease remain limited. More rigorous, large-scale human clinical trials are necessary to establish its therapeutic role and safety profile for this condition.

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Other ingredients used for Fatty Liver Disease

Akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
L-glutathione
L-methionine
L-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic compounds
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
Algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
Alpha methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
Camelina Oil
Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fucoidan
Fiber
Fucosterol
Fatty acids
Flavanones
Fucoxanthin
Flavonolignan
Glutathione
Hydroxycinnamic acid
Hydroxytyrosol
Isosilybin
Jaboticaba
Jurubeba
Job's Tears
Kefir
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Lactobacillus plantarum
Limonoid
Legume protein
Mangiferin
Myricetin
Monounsaturated Fat
Marine fat
Naringenin
Oleuropein
Oolong Tea
Oligosaccharides
Oxymatrine
Ornithine l-aspartic acid
Oleoylethanolamide
Osthole
Phellodendron
Puerarin
Phlorizin
Phaeophyceae
Pinitol
Phlorotannins
Polydatin
Phthalides
Pu-Er Tea
Purple Tea
Punicalagins
Rebaudioside
Rapeseed Oil
Rhubarb
Schizochytrium Oil
Schizochytrium
Silybin
Syringic acid
Salvianolic acid
Salacia
Schisandrins
Silydianin
Silychristin
S-allylcysteine
Sesamin
Sinensetin
Tetradecylthioacetic acid
Tyrosol
Taxifolin
Thistle
Tangeretin
Tanshinone
trehalose
Taurine
Theabrownin
Ursolic Acid
Varuna
Wax Gourd
Wakame
walnut
Yacon
Yin Chen
Zucchini

Products containing Astragaloside

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