Evidence supporting the use of: Berberine
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Berberine is a bioactive compound extracted from several plants used in traditional Chinese and Ayurvedic medicine. In recent years, scientific research has investigated its potential for supporting the management of non-alcoholic fatty liver disease (NAFLD). Multiple studies, including randomized controlled trials and meta-analyses, have demonstrated that berberine supplementation can reduce liver fat content, improve liver enzymes (such as ALT and AST), and enhance insulin sensitivity in patients with NAFLD. The proposed mechanisms by which berberine exerts these effects include activation of AMP-activated protein kinase (AMPK), reduction of de novo lipogenesis, improvement of lipid metabolism, and anti-inflammatory actions.

A 2012 study published in Hepatology found that berberine significantly improved hepatic steatosis and insulin resistance in patients with NAFLD over a 16-week period. Several systematic reviews and meta-analyses published since then (e.g., in Frontiers in Pharmacology, 2019, and Phytotherapy Research, 2021) support these findings, though they also note that larger, longer-term studies are needed to confirm efficacy and safety.

Overall, berberine's use for fatty liver disease is supported by a growing body of scientific evidence, though it is not yet considered a first-line therapy and should be used adjunctively with lifestyle interventions. Patients should consult healthcare providers before starting berberine, as it may interact with other medications.

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Other ingredients used for Fatty Liver Disease

4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Acacetin
Adzuki bean
Akkermansia muciniphila
Algae
algal oil
Algal protein
Alisma
Alpha methyl tetradecylthioacetic acid
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
Anemarrhena
anemarrhena asphodeloides
anthocyanins
Antrodia camphorata
apigenin
apocynin
arabinoxylan
argan nut oil
arjun tree
arjuna
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
astaxanthin
astragaloside
avocado
baicalein
baicalin
banaba
barberry
barley
beet
berberine
Berberis (unspecified)
betanin
Bifidobacteria
Bifidobacterium bifidum
Bifidobacterium longum
bile acid
black garlic
Blakeslea trispora
borotutu
branched-chain amino acids
Brassica
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brutieridin
butyrate triglyceride
butyric acid
camelina oil
carnosic acid
carqueja
catechins
caterpillar mushroom
Caulerpa okamurae
cauliflower
chebulic acid
chia seed
chicory
Chitin-Glucan Complex
chlorella
chlorogenic acid
chokeberry
choline
coix
conjugated linoleic acid (CLA)
copalchi
coriander
corilagin
corosolic acid
crocetin
cruciferous
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curcumin
cyclodextrin
cynarin
cynaropicrin
D-Pinitol
dandelion
danshen
decursin
diallyl disulfide (DADS)
diallyl sulfide
dihydromyricetin
diosgenin
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eicosapentaenoic acid
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EPA (eicosapentaenoic acid)
epicatechin
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ergothioneine
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erythrodiol
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fenugreek
ferulic acid
fiber
fiber blend (proprietary)
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fish protein
flavanones
flavonolignan
flavonols
flaxseed
fucoidan
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fucoxanthin
ganoderma
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grape
hesperetin
hydroxycinnamic acid
hydroxytyrosol
isosilybin
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jiaogulan
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l-carnitine
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mangiferin
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nicotinamide riboside
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omega-9 fatty acids
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ornithine L-aspartic acid
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palmitoleic acid
perilla
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phlorizin
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phosphatidylcholine
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polyphenols
prebiotic blend (proprietary)
psyllium
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punicalagins
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rapeseed oil
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seaweed
sesame
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silymarin
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spirulina
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