Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium longum is a probiotic bacterium that has been investigated for its potential role in supporting or treating Non-Alcoholic Fatty Liver Disease (NAFLD). Several preclinical and a limited number of clinical studies suggest that B. longum may help improve liver health by modulating the gut microbiota, reducing intestinal inflammation, and subsequently decreasing the influx of pro-inflammatory molecules to the liver via the gut-liver axis. In animal models, supplementation with B. longum has been shown to reduce hepatic fat accumulation, lower liver enzymes, and decrease markers of inflammation and oxidative stress. Small-scale human studies, including randomized controlled trials, have indicated that formulations containing B. longum (often in combination with other probiotics and prebiotics) may reduce liver fat, improve insulin resistance, and decrease markers of liver damage in individuals with NAFLD.

However, the number of high-quality human studies remains limited, and results are somewhat inconsistent, with most trials using multi-strain probiotic blends or synbiotics rather than B. longum alone. Mechanistically, B. longum is thought to restore gut barrier function, reduce endotoxemia (leakage of bacterial toxins into the bloodstream), and modulate immune responses, all of which are implicated in the progression of fatty liver disease. Overall, while there is a growing scientific basis for the use of B. longum in NAFLD, the current evidence is modest (hence the rating of 2/5), and further large-scale, well-controlled clinical trials are needed to confirm efficacy and clarify optimal dosing and strain selection.

More about bifidobacterium longum
More about Fatty Liver Disease

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