Evidence supporting the use of: Crocetin
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Crocetin, a carotenoid compound found in saffron (Crocus sativus L.), has attracted scientific interest for its potential hepatoprotective effects, including in the context of non-alcoholic fatty liver disease (NAFLD). Several preclinical studies using animal models have shown that crocetin can attenuate hepatic steatosis, reduce oxidative stress, and improve liver function markers. These effects are thought to be mediated through its antioxidant and anti-inflammatory properties, as well as modulation of lipid metabolism pathways. For instance, studies on high-fat diet-induced NAFLD in mice have demonstrated that crocetin supplementation leads to a reduction in liver triglyceride accumulation and downregulation of genes involved in lipogenesis (PMID: 32887536). However, the evidence remains limited to animal and in vitro studies; there are currently no large, high-quality clinical trials in humans confirming its efficacy for fatty liver disease. Thus, while there is a scientific rationale and some preclinical support for crocetin's use in fatty liver disease, the overall level of evidence is still preliminary (rated 2 out of 5), and its use should be considered experimental until further research, including human trials, is conducted.

More about Crocetin
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alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
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barberry
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bifidobacterium bifidum
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cyclodextrin
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diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
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fish oil
fish protein
flavonols
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hesperetin
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l-carnitine
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l-methionine
l-taurine
lecithin
licorice root
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marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
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Products containing Crocetin

We currently have no products on Vitabase that contain this ingredient.