Evidence supporting the use of: Crocetin
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Crocetin, a carotenoid compound found in saffron (Crocus sativus L.), has attracted scientific interest for its potential hepatoprotective effects, including in the context of non-alcoholic fatty liver disease (NAFLD). Several preclinical studies using animal models have shown that crocetin can attenuate hepatic steatosis, reduce oxidative stress, and improve liver function markers. These effects are thought to be mediated through its antioxidant and anti-inflammatory properties, as well as modulation of lipid metabolism pathways. For instance, studies on high-fat diet-induced NAFLD in mice have demonstrated that crocetin supplementation leads to a reduction in liver triglyceride accumulation and downregulation of genes involved in lipogenesis (PMID: 32887536). However, the evidence remains limited to animal and in vitro studies; there are currently no large, high-quality clinical trials in humans confirming its efficacy for fatty liver disease. Thus, while there is a scientific rationale and some preclinical support for crocetin's use in fatty liver disease, the overall level of evidence is still preliminary (rated 2 out of 5), and its use should be considered experimental until further research, including human trials, is conducted.

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Other ingredients used for Fatty Liver Disease

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alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
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canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
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L-methionine
L-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic compounds
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
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psyllium
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tocotrienols
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seaweed
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Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
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chlorogenic acid
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DL-Methionine
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D-Pinitol
Diosgenin
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epicatechin
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Products containing Crocetin

We currently have no products on Vitabase that contain this ingredient.