Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diallyl disulfide (DADS), a major organosulfur compound found in garlic, has been investigated for its potential benefits in non-alcoholic fatty liver disease (NAFLD) and related hepatic disorders. The scientific basis for its use primarily comes from preclinical studies. In animal models of fatty liver disease, DADS has demonstrated hepatoprotective effects, including reduction of hepatic fat accumulation, improvement in liver enzyme profiles (such as ALT and AST), and attenuation of inflammation and oxidative stress. Mechanistically, DADS is thought to exert its effects by modulating lipid metabolism pathways, such as downregulating the expression of lipogenic genes (e.g., SREBP-1c, FAS), enhancing antioxidant defenses (increasing activities of SOD, CAT, and GPx), and reducing inflammatory cytokine production.

However, it is important to note that while these results are promising, the evidence is largely limited to animal and in vitro studies. There are very few, if any, robust clinical trials in humans specifically examining the effects of isolated DADS on fatty liver disease. Some small studies have explored garlic extracts (which contain DADS) in the context of liver health, but attributing effects specifically to DADS is challenging. Therefore, while scientific interest exists and preclinical evidence supports potential benefit, more rigorous human research is needed to confirm efficacy and safety. At present, the evidence supporting the use of DADS for fatty liver disease is preliminary (rated 2/5).

More about diallyl disulfide (DADS)
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

Other health conditions supported by diallyl disulfide (DADS)

Products containing diallyl disulfide (DADS)

Designs For Health Allicillin™