Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dihydromyricetin (DHM), also known as ampelopsin, is a flavonoid primarily derived from the Japanese raisin tree (Hovenia dulcis). Recent scientific research has explored its potential benefits in supporting liver health, especially concerning non-alcoholic fatty liver disease (NAFLD). Preclinical studies in animal models have shown that DHM can reduce hepatic lipid accumulation, improve insulin sensitivity, and attenuate inflammation and oxidative stress, which are key factors in the progression of fatty liver disease. The proposed mechanisms include modulation of lipid metabolism pathways such as activation of AMP-activated protein kinase (AMPK) and regulation of genes involved in fatty acid oxidation and synthesis. Some studies have also reported that DHM may enhance autophagy and reduce endoplasmic reticulum stress in hepatocytes, contributing to its hepatoprotective effects. However, the evidence remains preliminary, as most studies to date have been conducted in vitro or in animal models. There are very limited human clinical trials evaluating DHM for fatty liver disease specifically. Therefore, while the mechanistic data and early animal results are promising and provide a scientific rationale for its use, robust clinical validation in humans is lacking. DHM is not widely recognized in traditional medicine specifically for fatty liver disease, making its use primarily driven by emerging scientific research rather than long-standing traditional practice.

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Other ingredients used for Fatty Liver Disease

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alpha-linolenic acid (ALA)
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arjun tree
artichoke
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barberry
barley
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bifidobacterium bifidum
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branched-chain amino acids
butyrate triglyceride
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catechins
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chia seed
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conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
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grape
hesperetin
kelp
l-carnitine
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L-methionine
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lecithin
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medium chain triglycerides (MCT)
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nicotinamide riboside
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oleic acid
olive
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omega-9 fatty acids
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epicatechin
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Other health conditions supported by Dihydromyricetin

Alcoholism
Fatty Liver Disease
Hangover
Inflammation
Liver Detoxification

Products containing Dihydromyricetin

We currently have no products on Vitabase that contain this ingredient.