Evidence supporting the use of: Eicosapentaenoic Acid
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid found primarily in fatty fish and fish oil supplements. Its use in supporting or treating non-alcoholic fatty liver disease (NAFLD) and related liver conditions is backed by a moderate level of scientific evidence. Clinical studies and meta-analyses have shown that supplementation with EPA, often in combination with docosahexaenoic acid (DHA), can reduce hepatic fat accumulation, improve liver enzyme levels (such as ALT and AST), and improve lipid profiles in patients with NAFLD. The proposed mechanisms include anti-inflammatory effects, reduction of hepatic triglyceride synthesis, and improvement of insulin sensitivity. Randomized controlled trials (RCTs) and systematic reviews published in journals such as Hepatology and Journal of Hepatology have reported statistically significant, though sometimes modest, benefits. However, the studies often vary in dose, duration, and whether EPA is isolated or combined with other omega-3s, and not all trials have found significant improvements in liver histology or fibrosis.

While the evidence is not universally consistent or robust enough to be considered standard therapy, major hepatology guidelines (such as those from the American Association for the Study of Liver Diseases) mention omega-3 fatty acids as a potential adjunct to lifestyle modification for NAFLD, particularly for improving hypertriglyceridemia. Therefore, the use of EPA for fatty liver disease is supported by a moderate level of scientific evidence, but more large-scale, long-term studies are needed to establish its efficacy and optimal use.

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Other ingredients used for Fatty Liver Disease

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algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
L-glutathione
L-methionine
L-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic compounds
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
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vitamin C
vitamin E
seaweed
mulberry
zinc
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jiaogulan
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punarnava
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Apocynin
Arjunolic acid
Borotutu
Brutieridin
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bile acid
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chlorogenic acid
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DL-Methionine
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epicatechin
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Erythrodiol
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Products containing Eicosapentaenoic Acid

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