Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Enicostemma littorale (commonly called "Mamajjaka" or "Indian Whitehead") is a medicinal herb traditionally used in Ayurveda and folk medicine, primarily for diabetes, liver disorders, and inflammation. Recent scientific studies have begun to explore its potential in managing Fatty Liver Disease (hepatic steatosis). Several preclinical studies (mainly in animal models) have demonstrated that Enicostemma littorale extracts can reduce liver fat accumulation, improve liver enzyme levels, and exert antioxidant and anti-inflammatory effects, all of which are beneficial in the context of fatty liver disease. For example, research published in peer-reviewed journals has shown that administration of Enicostemma littorale extract to rats fed a high-fat diet resulted in significant reduction in liver triglyceride levels and improved histopathological features of the liver. The proposed mechanisms include inhibition of lipid peroxidation, enhancement of antioxidant defenses (such as increased activity of superoxide dismutase and catalase), and modulation of inflammatory cytokines. However, there is a lack of robust clinical trials in humans to confirm efficacy and safety for this indication. While the traditional use for liver health provides some support for its application, current scientific validation is mostly limited to animal studies or in vitro experiments. Thus, while there is a scientific basis for its use in fatty liver disease, the evidence remains preliminary and further well-designed human studies are needed for conclusive validation.

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