Evidence supporting the use of: Epicatechin
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epicatechin is a flavonoid found in foods like cocoa, green tea, and certain fruits. Its use in supporting or treating Fatty Liver Disease (non-alcoholic fatty liver disease, NAFLD) is based on emerging scientific evidence, primarily from animal and in vitro studies. Several preclinical studies have demonstrated that epicatechin can improve hepatic lipid metabolism, reduce oxidative stress, and decrease inflammation—factors implicated in the pathogenesis of NAFLD. For example, research in rodent models has shown that dietary supplementation with epicatechin attenuates liver fat accumulation, improves insulin sensitivity, and reduces liver enzyme levels. The mechanisms appear to involve activation of AMP-activated protein kinase (AMPK), enhancement of mitochondrial function, and modulation of genes involved in lipid synthesis and breakdown. However, clinical data in humans are currently limited. Small pilot studies and indirect evidence from research on cocoa flavonoids suggest potential benefits, but there are no large-scale, high-quality randomized controlled trials specifically assessing epicatechin for NAFLD in humans. While the mechanistic rationale and animal data are promising, the evidence base remains preliminary. As such, epicatechin cannot yet be considered a validated or standard treatment for fatty liver disease, but it is an area of active research. Until more robust human studies are available, its use should be considered experimental.

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Products containing epicatechin

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