Evidence supporting the use of: Ergothioneine
For the health condition: Fatty Liver Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Ergothioneine is a naturally occurring amino acid derivative with antioxidant properties, found in foods such as mushrooms. While ergothioneine is not a traditional remedy for fatty liver disease (non-alcoholic fatty liver disease, NAFLD), recent scientific research has begun to explore its potential benefits for this condition. Preclinical studies, primarily in animal models, suggest that ergothioneine may help protect the liver from oxidative stress and inflammation—two key mechanisms involved in the progression of fatty liver disease.
For example, several mouse studies have indicated that ergothioneine supplementation can reduce liver fat accumulation, decrease markers of liver injury (such as ALT and AST), and improve insulin sensitivity. These effects are thought to result from ergothioneine’s ability to scavenge reactive oxygen species and modulate inflammatory pathways. A few small human observational studies have linked higher ergothioneine levels with better metabolic health, but direct clinical trials investigating its effectiveness in treating or preventing fatty liver disease in humans are lacking as of mid-2024.
Overall, while the mechanistic rationale is strong and early animal data are promising, the evidence is not yet robust or direct enough to strongly support ergothioneine as a treatment for fatty liver disease in humans. More clinical research is needed. Thus, the scientific evidence currently rates as modest (2/5).
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Acacetin
Adzuki bean
Akkermansia muciniphila
Algae
algal oil
Algal protein
Alisma
Alpha methyl tetradecylthioacetic acid
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
Anemarrhena
anemarrhena asphodeloides
anthocyanins
Antrodia camphorata
apigenin
apocynin
arabinoxylan
argan nut oil
arjun tree
arjuna
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
astaxanthin
astragaloside
avocado
baicalein
baicalin
banaba
barberry
barley
beet
berberine
Berberis (unspecified)
betanin
Bifidobacteria
Bifidobacterium bifidum
Bifidobacterium longum
bile acid
black garlic
Blakeslea trispora
borotutu
branched-chain amino acids
Brassica
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brutieridin
butyrate triglyceride
butyric acid
camelina oil
carnosic acid
carqueja
catechins
caterpillar mushroom
Caulerpa okamurae
cauliflower
chebulic acid
chia seed
chicory
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chlorella
chlorogenic acid
chokeberry
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coix
conjugated linoleic acid (CLA)
copalchi
coriander
corilagin
corosolic acid
crocetin
cruciferous
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curcumin
cyclodextrin
cynarin
cynaropicrin
D-Pinitol
dandelion
danshen
decursin
diallyl disulfide (DADS)
diallyl sulfide
dihydromyricetin
diosgenin
dithiolthiones
DL-Methionine
eicosapentaenoic acid
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eriocitrin
erythrodiol
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ferulic acid
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fish oil
fish protein
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flavonolignan
flavonols
flaxseed
fucoidan
fucosterol
fucoxanthin
ganoderma
ginger
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grape
hesperetin
hydroxycinnamic acid
hydroxytyrosol
isosilybin
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jiaogulan
Job\'s tears
Jurubeba
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kelp
l-carnitine
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L-methionine
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lecithin
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licorice root
limonoid
lingzhi
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mangiferin
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medium chain triglycerides (MCT)
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nicotinamide riboside
nopal
oleanolic acid
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omega-3 fatty acids
omega-9 fatty acids
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ornithine L-aspartic acid
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palmitoleic acid
perilla
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phenolic compounds
phlorizin
phlorotannins
phosphatidylcholine
phospholipids
Phthalides
picrorhiza kurroa
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polyphenols
prebiotic blend (proprietary)
psyllium
pu-er tea
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punarnava
punicalagins
purple tea
rapeseed oil
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reishi mushroom
resveratrol
rhubarb
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Schizochytrium Oil
seaweed
sesame
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Silybin
Silychristin
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silymarin
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spirulina
Syringic acid
Tangeretin
Tanshinone
Taurine
Taxifolin
Tetradecylthioacetic acid
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tocotrienols
Trans-pterostilbene
Trehalose
tributyrin
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turmeric
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vitamin E
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