Eucommia ulmoides (Du Zhong) is a traditional Chinese medicinal herb that has been investigated for its potential effects on metabolic disorders, including non-alcoholic fatty liver disease (NAFLD). Several preclinical studies using animal models have suggested that extracts of Eucommia ulmoides may reduce hepatic lipid accumulation, improve insulin resistance, and attenuate liver inflammation. These effects are thought to be mediated by bioactive compounds such as lignans, iridoids, and flavonoids, which may regulate lipid metabolism and oxidative stress pathways.

For instance, research published in peer-reviewed journals (e.g., Journal of Ethnopharmacology, Phytomedicine) has demonstrated that Eucommia ulmoides extract can decrease liver triglyceride content and improve liver histology in rodent models of diet-induced fatty liver. Mechanistic studies suggest modulation of AMPK signaling and inhibition of inflammatory cytokine production as possible pathways.

However, the current body of evidence is limited to animal experiments and in vitro studies. There are no high-quality clinical trials in humans to confirm efficacy or safety for fatty liver disease. Thus, while there is scientific rationale and preliminary support, the evidence remains weak (rated 2/5) and insufficient for clinical recommendation at this time.