Evidence supporting the use of: Flavonolignan
For the health condition: Fatty Liver Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Flavonolignans, particularly those found in silymarin (the active extract of Silybum marianum or milk thistle), have been investigated for their effects on fatty liver disease, including non-alcoholic fatty liver disease (NAFLD). Several clinical studies and meta-analyses suggest that silymarin, rich in flavonolignans such as silybin, may exert hepatoprotective effects. Proposed mechanisms include antioxidant activity, anti-inflammatory effects, and improved insulin sensitivity, all of which are relevant to the pathogenesis of fatty liver disease.
A number of randomized controlled trials have reported modest improvements in liver enzyme levels (such as ALT and AST) and some evidence of improved liver histology in patients with NAFLD or alcoholic fatty liver disease when treated with silymarin-based preparations. However, the magnitude of benefit is typically small to moderate, and not all studies agree on clinically significant outcomes. Safety profiles are generally favorable.
Although silymarin and its flavonolignans have a long history of traditional use for liver ailments, contemporary support for their use in fatty liver disease is primarily scientific, with evidence suggesting potential but still somewhat limited efficacy. The overall quality of evidence is moderate (rated 3/5), reflecting a combination of positive but not definitive trial outcomes, heterogeneity among study designs, and a need for larger, more rigorous trials.
Other ingredients used for Fatty Liver Disease
4-hydroxyisoleucine7,14-Hydroxy-Docosapentaenoic Acid
Acacetin
Adzuki bean
Akkermansia muciniphila
Algae
algal oil
Algal protein
Alisma
Alpha methyl tetradecylthioacetic acid
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
Anemarrhena
anemarrhena asphodeloides
anthocyanins
Antrodia camphorata
apigenin
apocynin
arabinoxylan
argan nut oil
arjun tree
arjuna
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
astaxanthin
astragaloside
avocado
baicalein
baicalin
banaba
barberry
barley
beet
berberine
Berberis (unspecified)
betanin
Bifidobacteria
Bifidobacterium bifidum
Bifidobacterium longum
bile acid
black garlic
Blakeslea trispora
borotutu
branched-chain amino acids
Brassica
Brown Algae
brutieridin
butyrate triglyceride
butyric acid
camelina oil
carnosic acid
carqueja
catechins
caterpillar mushroom
Caulerpa okamurae
cauliflower
chebulic acid
chia seed
chicory
Chitin-Glucan Complex
chlorella
chlorogenic acid
chokeberry
choline
coix
conjugated linoleic acid (CLA)
copalchi
coriander
corilagin
corosolic acid
crocetin
cruciferous
Curcuma
curcumin
cyclodextrin
cynarin
cynaropicrin
D-Pinitol
dandelion
danshen
decursin
diallyl disulfide (DADS)
diallyl sulfide
dihydromyricetin
diosgenin
dithiolthiones
DL-Methionine
eicosapentaenoic acid
Enicostemma littorale
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
erythrodiol
Eucommia ulmoides
fatty acids
fenugreek
ferulic acid
fiber
fiber blend (proprietary)
fish oil
fish protein
flavanones
flavonolignan
flavonols
flaxseed
fucoidan
fucosterol
fucoxanthin
ganoderma
ginger
Glutathione
grape
hesperetin
hydroxycinnamic acid
hydroxytyrosol
isosilybin
Jaboticaba
jiaogulan
Job\'s tears
Jurubeba
Kefir
kelp
l-carnitine
L-glutathione
L-methionine
L-taurine
Lactobacillus plantarum
lecithin
Legume protein
licorice root
limonoid
lingzhi
liquid liver fractions
Lycium
mangiferin
Marine fat
Marine lipid
medium chain triglycerides (MCT)
Milk thistle
Monounsaturated fat
Morus
Mulberry
Myricetin
Naringenin
Naringin
Niacin (vitamin B3)
nicotinamide riboside
nopal
oleanolic acid
oleic acid
Oleoylethanolamide
Oleuropein
Oligosaccharides
olive
omega-3 fatty acids
omega-9 fatty acids
oolong tea
ornithine L-aspartic acid
Osthole
Oxymatrine
palmitoleic acid
perilla
Phaeophyceae
Phellodendron
phenolic compounds
phlorizin
phlorotannins
phosphatidylcholine
phospholipids
Phthalides
picrorhiza kurroa
Pinitol
Polydatin
polyphenols
prebiotic blend (proprietary)
psyllium
pu-er tea
Puerarin
punarnava
punicalagins
purple tea
rapeseed oil
Rebaudioside
reishi mushroom
resveratrol
rhubarb
S-allylcysteine
Salacia
Salvianolic acid
Schisandrins
Schizochytrium
Schizochytrium Oil
seaweed
sesame
Sesamin
Silybin
Silychristin
Silydianin
silymarin
Sinensetin
spirulina
Syringic acid
Tangeretin
Tanshinone
Taurine
Taxifolin
Tetradecylthioacetic acid
Theabrownin
Thistle
tocotrienols
Trans-pterostilbene
Trehalose
tributyrin
Trimethylglycine (TMG)
Triphala
turmeric
Tyrosol
Urolithin A
Ursolic Acid
Varuna
vitamin C
vitamin E
Wakame
Walnut
Wax Gourd
Yacon
Yin Chen
Zinc
Zucchini
β-nicotinamide mononucleotide (NMN)
Other health conditions supported by flavonolignan
AlcoholismCancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cirrhosis of the Liver
Diabetes
Fatty Liver Disease
Hepatitis
Inflammation
Liver Detoxification