Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonols are a class of flavonoids found abundantly in fruits, vegetables, and certain medicinal plants, with quercetin and kaempferol among the most studied. Interest in flavonols for the support and treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and related metabolic liver conditions arises from their antioxidant, anti-inflammatory, and lipid-lowering properties. Several preclinical studies (in vitro and animal models) have shown that flavonols can reduce hepatic fat accumulation, decrease oxidative stress, and modulate inflammatory pathways implicated in the progression of fatty liver disease. For example, quercetin has been demonstrated to attenuate liver steatosis in animal models by regulating lipid metabolism genes and inhibiting pro-inflammatory cytokines.

In humans, evidence is more limited but promising. Some small clinical trials and observational studies suggest that higher dietary intake of flavonol-rich foods is associated with improved liver enzyme profiles and reduced risk factors for NAFLD. However, robust randomized controlled trials specifically testing isolated flavonols as a treatment for fatty liver disease are lacking. Most human data are extrapolated from broader dietary patterns rather than supplementation studies. Thus, while the mechanistic rationale and preliminary animal/human data support potential benefits, the clinical evidence remains moderate. Further large-scale, well-designed trials are needed to confirm efficacy and establish appropriate dosing.

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Douglas Laboratories Ultra Preventive 50+ -EZ Swallow