Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Grapes, particularly red and black varieties, contain a range of polyphenolic compounds, most notably resveratrol, which have been studied for their potential benefits in treating or supporting non-alcoholic fatty liver disease (NAFLD). The scientific interest in grapes for liver health primarily stems from preclinical studies and some small clinical trials. Resveratrol and other grape polyphenols exhibit antioxidant, anti-inflammatory, and lipid-lowering properties in laboratory models. Animal studies have shown that grape extracts can reduce hepatic fat accumulation, oxidative stress, and inflammatory markers in liver tissue. Human evidence is more limited but growing. Some small clinical trials suggest that supplementation with grape extracts or resveratrol can improve liver enzymes (ALT, AST) and markers of inflammation in individuals with NAFLD. However, results are mixed: some studies report modest benefits, while others show no significant improvement compared to placebo. The effective dose, duration, and specific grape-derived compounds needed for significant clinical benefit remain unclear. Furthermore, most of the evidence comes from isolated compounds like resveratrol rather than whole grapes or grape juice, and the bioavailability of these compounds is relatively low in humans. In summary, while there is emerging scientific evidence supporting the use of grape-derived compounds for fatty liver disease, it remains preliminary. Larger, well-designed human trials are needed to confirm efficacy and to establish guidelines for clinical use.

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