Evidence supporting the use of: L-carnitine
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-carnitine has a scientific basis for use in the management of Non-Alcoholic Fatty Liver Disease (NAFLD), with several studies investigating its efficacy. L-carnitine is a naturally occurring amino acid derivative involved in mitochondrial fatty acid transport and energy metabolism. In patients with NAFLD, impaired fatty acid oxidation is a key pathophysiological feature, and L-carnitine supplementation is hypothesized to enhance hepatic fatty acid oxidation, reduce lipid accumulation, and improve liver function.

A number of randomized controlled trials (RCTs) and meta-analyses have evaluated L-carnitine's impact on liver enzyme levels, liver fat content, and markers of inflammation. For example, a 2018 meta-analysis of RCTs found that L-carnitine supplementation significantly improved liver enzyme levels (ALT, AST) and reduced markers of liver fat accumulation in patients with NAFLD. Another 2022 systematic review concluded that L-carnitine supplementation was associated with improvements in hepatic steatosis and some metabolic parameters. However, the evidence is not unequivocal: studies have shown variability in dosage, duration, and patient populations, and some trials have failed to show statistically significant benefits.

Overall, while the use of L-carnitine for fatty liver disease is not yet universally endorsed by clinical guidelines, the existing body of scientific evidence supports a potential benefit, particularly as an adjunct to lifestyle and dietary interventions. More large-scale, long-term studies are needed to confirm its efficacy and establish optimal dosing protocols.

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anthocyanins
arjun tree
artichoke
astaxanthin
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barberry
barley
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bifidobacterium bifidum
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EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
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flavonols
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hesperetin
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l-methionine
l-taurine
lecithin
licorice root
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marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
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butyric acid
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resveratrol
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tocotrienols
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