Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutathione is a tripeptide and a major intracellular antioxidant that plays a crucial role in detoxification and cellular protection from oxidative stress. Its use in supporting or treating Fatty Liver Disease (FLD), particularly non-alcoholic fatty liver disease (NAFLD), is based on the understanding that oxidative stress and impaired antioxidant defenses are central to the pathogenesis of FLD. Clinical studies, though limited in both size and number, have suggested potential benefits. For example, a 2017 pilot study published in BMC Gastroenterology showed that oral glutathione supplementation (300 mg/day for four months) significantly reduced alanine aminotransferase (ALT) levels and improved markers of hepatic fat accumulation in NAFLD patients. Animal studies further support the role of glutathione in reducing liver fat and improving liver enzyme profiles by enhancing antioxidant capacity and supporting mitochondrial function.

However, the overall evidence remains preliminary, with few randomized controlled trials and inconsistent results regarding dosing and bioavailability. Glutathione is not widely recognized as a standard therapy for FLD in major clinical guidelines, and its use is typically as an adjunct rather than a replacement for established interventions like weight loss and management of metabolic risk factors. In summary, while there is a plausible scientific rationale and some supportive clinical data, the strength of evidence is modest, warranting a rating of 2 out of 5.

More about L-glutathione
More about Fatty Liver Disease

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