Evidence supporting the use of: L-Gluthathione
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-Glutathione is an endogenous antioxidant that plays a key role in cellular detoxification and protection against oxidative stress. In the context of Fatty Liver Disease (both NAFLD and alcoholic fatty liver), oxidative stress is a major contributor to liver cell injury and disease progression. Several scientific studies, including small clinical trials and animal studies, have investigated L-glutathione’s potential in supporting liver health. Some clinical evidence suggests that intravenous or oral glutathione may improve liver function tests (e.g., ALT, AST) and decrease markers of oxidative stress in patients with fatty liver disease, particularly those with nonalcoholic steatohepatitis (NASH) or alcoholic liver disease.

A notable open-label pilot study (2017, Journal of Gastroenterology and Hepatology) found that oral glutathione supplementation (300 mg/day for 4 months) significantly reduced ALT levels and improved hepatic steatosis in NAFLD patients. However, these findings are preliminary, and larger, controlled trials are needed to confirm efficacy. Mechanistically, glutathione's antioxidant properties and its involvement in modulating inflammatory and fibrotic pathways provide a plausible rationale for its use.

Despite promising early data, the overall quality and quantity of evidence remain moderate, and glutathione is not yet a standard therapy for fatty liver disease. Its use is primarily justified by mechanistic rationale and preliminary clinical data, rather than robust, large-scale trials or long-standing tradition.

More about L-Gluthathione
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akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
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cauliflower
chia seed
chicory
chlorella
chokeberry
choline
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turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
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vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
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anemarrhena asphodeloides
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Ampelopsin
Algal protein
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Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
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bile acid
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chlorogenic acid
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DL-Methionine
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D-Pinitol
Diosgenin
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epicatechin
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walnut
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Products containing L-Gluthathione

We currently have no products on Vitabase that contain this ingredient.