Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-methionine is an essential amino acid involved in numerous metabolic processes, including methylation and the synthesis of S-adenosylmethionine (SAMe), an important methyl donor. Its use in supporting or treating Fatty Liver Disease (hepatic steatosis) is based on its role in liver function and lipid metabolism. Methionine serves as a precursor to SAMe, which is involved in the metabolism of phospholipids and helps in the export of fat from the liver. Deficiency of methionine in experimental animal models can induce fatty liver, suggesting its importance in preventing hepatic steatosis.

However, the direct scientific evidence for L-methionine supplementation as a treatment for Fatty Liver Disease in humans is limited and not conclusive. Most clinical research has focused on SAMe rather than methionine itself. While some studies have reported benefits of SAMe in improving liver enzyme levels and histology in liver diseases, robust clinical trials specifically on L-methionine supplementation for fatty liver are lacking. Furthermore, excessive methionine intake could potentially be harmful, especially in individuals with impaired liver function.

In summary, while there is a plausible biochemical rationale and supportive evidence from animal studies, and while methionine deficiency is linked to fatty liver, there is insufficient high-quality human data to strongly support the use of L-methionine supplementation for treating Fatty Liver Disease. Thus, the scientific evidence is modest (rated 2/5), and its use should be approached with caution.

More about L-methionine
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