Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mulberry (Morus alba and related species) has been traditionally used in various systems of medicine, particularly in Asia, for its purported benefits in managing blood sugar and supporting liver health. In recent years, there has been a growing body of preclinical scientific research investigating its potential role in supporting or treating Fatty Liver Disease (non-alcoholic fatty liver disease, NAFLD). Animal studies have demonstrated that mulberry extracts may exert hepatoprotective effects, likely due to their high content of bioactive compounds such as flavonoids, alkaloids, and anthocyanins. These compounds have been shown to reduce oxidative stress, inhibit lipid accumulation in the liver, and improve insulin sensitivity in rodent models of NAFLD. For example, studies published in peer-reviewed journals have reported that mulberry leaf extract can decrease serum triglycerides and liver enzymes, as well as histological markers of liver steatosis in mice fed a high-fat diet.

However, it is important to note that clinical evidence in humans is limited, and most of the current data are derived from animal studies or in vitro experiments. Only a few small-scale human studies exist, and while some report improvement in liver enzyme levels or metabolic parameters, the results are preliminary. No major clinical guidelines currently recommend mulberry as a treatment for fatty liver disease. Thus, while there is a scientific rationale and early promising data, the overall evidence is still weak and does not yet warrant strong clinical recommendations.

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