Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Niacin (vitamin B3) has some scientific rationale for use in fatty liver disease (specifically nonalcoholic fatty liver disease, or NAFLD), but the overall evidence is limited and primarily preliminary. Niacin functions as a precursor for NAD⁺ and NADP⁺, which are essential coenzymes in cellular metabolism, including lipid metabolism. Disrupted lipid metabolism is a hallmark of NAFLD. Animal studies have shown that niacin supplementation can reduce liver fat accumulation, improve lipid profiles, and decrease inflammation and oxidative stress in the liver. For example, research in mice has indicated that niacin can lower hepatic triglyceride content and improve insulin sensitivity. Proposed mechanisms include inhibition of hepatic de novo lipogenesis and improvement of mitochondrial function.

In human studies, niacin is best known for its effects on dyslipidemia (lowering LDL cholesterol and triglycerides, raising HDL cholesterol), which are risk factors associated with NAFLD. However, direct clinical evidence supporting niacin’s efficacy in treating NAFLD or reversing fatty liver in humans is sparse. A few small pilot studies have suggested potential benefit, but robust randomized controlled trials are lacking. Furthermore, niacin supplementation can cause adverse effects such as flushing, liver toxicity at high doses, and glucose intolerance, which complicate its use, especially in those with liver disease.

In summary, while there is some scientific rationale and limited preliminary evidence for niacin’s use in fatty liver disease, it is not yet established as an evidence-based or widely endorsed therapy for this condition.

More about niacin (vitamin B3)
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

Other health conditions supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Integrative Therapeutics Active B-Complex
Metagenics AdvaClear
Metagenics AdvaClear
Douglas Laboratories B-Complex
Pure Encapsulations B-Complex Plus
Pure Encapsulations B-Complex Plus
Designs For Health B-Supreme
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Thorne Basic B Complex
Metagenics Bone Builder Active
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Integrative Therapeutics Detoxication Factors
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Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
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Pure Encapsulations Energize Plus™ Pure Pack
Metagenics Fem Prenatal®
Integrative Therapeutics Flush-Free Niacin
Metagenics Glutagenics
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Vitabase Hair, Skin & Nails Formula
Pure Encapsulations Hair/Skin/Nails Ultra
Metagenics ImmuCore
Metagenics Immune Defense Pack
Metagenics Ketogenic Shake Chocolate
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Klean Athlete Klean Multivitamin ™
Vitabase Life's Essentials Plus
Designs For Health Liposomal B Supreme
Metagenics Lipotain®
Thorne MediClear Plus
Thorne Men's Multi 50+
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Pure Encapsulations Multi t/d
Pure Encapsulations Multi t/d
Thorne Multi-Vitamin Elite NSF
Thorne Multi-Vitamin Elite NSF
Metagenics Multigenics®
Metagenics Multigenics Intensive Care
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Metagenics Multigenics without Iron
Integrative Therapeutics Multiplex-1 No-Iron
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations Niacinamide
Pure Encapsulations Niacitol® 500 mg
Pure Encapsulations Niacitol® (no-flush niacin) 650 mg
Douglas Laboratories Niatab ™ 500
Metagenics Niatain®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950® A without Copper & Iron
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Pure Encapsulations Nutrient 950® with Vitamin K
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Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations Nutrient 950® without Iron
Integrative Therapeutics Nutrivitamin No-Iron
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
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Designs For Health PaleoMeal®
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Pure Encapsulations PureGenomics® Multivitamin
Pure Encapsulations PureGenomics® UltraMultivitamin
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Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Douglas Laboratories Ultra B-Complex
Pure Encapsulations Ultra B-Complex with PQQ
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Metagenics Ultra Glucose Control Chocolate
Metagenics Ultra Glucose Control Vanilla
Metagenics Ultra Glucose Control Vanilla
Metagenics Ultra Potent-C 1000
Metagenics Ultra Potent-C 500
Metagenics Ultra Potent-C Chewable
Metagenics Ultra Potent-C Powder
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Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Douglas Laboratories Ultra Preventive® X
Pure Encapsulations Ultra Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
Metagenics UltraMeal Advanced Protein French Vanilla
Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
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Metagenics UltraMeal Daily Support Mixed Berry
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Pure Encapsulations VisionPro Nutrients
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Metagenics Wellness Essentials® Daily Packs
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Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
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Pure Encapsulations Women's Nutrients
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