Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Niacin (vitamin B3) has some scientific rationale for use in fatty liver disease (specifically nonalcoholic fatty liver disease, or NAFLD), but the overall evidence is limited and primarily preliminary. Niacin functions as a precursor for NAD⁺ and NADP⁺, which are essential coenzymes in cellular metabolism, including lipid metabolism. Disrupted lipid metabolism is a hallmark of NAFLD. Animal studies have shown that niacin supplementation can reduce liver fat accumulation, improve lipid profiles, and decrease inflammation and oxidative stress in the liver. For example, research in mice has indicated that niacin can lower hepatic triglyceride content and improve insulin sensitivity. Proposed mechanisms include inhibition of hepatic de novo lipogenesis and improvement of mitochondrial function.

In human studies, niacin is best known for its effects on dyslipidemia (lowering LDL cholesterol and triglycerides, raising HDL cholesterol), which are risk factors associated with NAFLD. However, direct clinical evidence supporting niacin’s efficacy in treating NAFLD or reversing fatty liver in humans is sparse. A few small pilot studies have suggested potential benefit, but robust randomized controlled trials are lacking. Furthermore, niacin supplementation can cause adverse effects such as flushing, liver toxicity at high doses, and glucose intolerance, which complicate its use, especially in those with liver disease.

In summary, while there is some scientific rationale and limited preliminary evidence for niacin’s use in fatty liver disease, it is not yet established as an evidence-based or widely endorsed therapy for this condition.

More about Niacin (vitamin B3)
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

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Products containing Niacin (vitamin B3)

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