Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Nopal (Opuntia ficus-indica, or prickly pear cactus) has been traditionally consumed in Mexico for a variety of health benefits, including liver health. In recent years, scientific research has begun to explore its potential role in managing Non-Alcoholic Fatty Liver Disease (NAFLD). Several animal studies and a limited number of human clinical trials suggest that nopal may help reduce liver fat accumulation, oxidative stress, and inflammation associated with NAFLD.

The beneficial effects are likely due to its high content of fiber, polyphenols, betalains, and antioxidants. For example, a 2020 randomized controlled trial published in the journal Phytotherapy Research found that overweight participants with NAFLD who consumed nopal for 12 weeks had significant reductions in liver fat, improved insulin sensitivity, and lower markers of inflammation compared to controls. Animal studies have demonstrated that nopal supplementation can decrease hepatic steatosis and improve lipid metabolism, likely by modulating oxidative stress and inflammatory responses.

However, while these results are promising, the body of evidence remains moderate, and larger, long-term human studies are needed to confirm these effects and establish optimal dosing. In summary, nopal’s use for fatty liver is supported both by tradition and emerging scientific studies, with a moderate (3/5) level of evidence as of 2024.

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