Evidence supporting the use of: Phospholipid
For the health condition: Fatty Liver Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Phospholipids, particularly in the form of polyenylphosphatidylcholine (PPC) extracted from soybeans, have been used as a supportive treatment for fatty liver disease (hepatic steatosis), especially in Eastern Europe and parts of Asia. The rationale is based on the role of phospholipids in cellular membrane repair and lipid metabolism. Several clinical trials and animal studies have explored their potential benefits in non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Some studies suggest that PPC may help stabilize hepatocyte membranes, reduce oxidative stress, and limit lipid peroxidation, potentially slowing the progression of liver damage.
However, the quality of scientific evidence is modest. Most clinical trials to date have been small, of short duration, or have methodological limitations such as lack of blinding or proper controls. Meta-analyses and systematic reviews note that while there are indications of benefit in biochemical markers and liver imaging, hard clinical endpoints (such as histological improvement or prevention of fibrosis) are not consistently demonstrated. Major liver associations, including AASLD and EASL, do not recommend phospholipids as standard therapy for fatty liver disease due to insufficient high-quality evidence. Thus, while there is some scientific rationale and preliminary data, robust clinical validation is lacking, and phospholipids should not be considered a primary treatment for fatty liver disease.
Other ingredients used for Fatty Liver Disease
akkermansia muciniphilaalgal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
Camelina Oil
Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fiber
Fatty acids
Rhubarb
walnut
Zucchini
Other health conditions supported by phospholipid
Alzheimer's DiseaseCancer Treatment (reducing side effects)
Cirrhosis of the Liver
Fatty Liver Disease
Inflammation
Liver Detoxification
Memory and Brain Function
Psoriasis
Stress
Ulcers
Wounds and Sores