Evidence supporting the use of: Polyunsaturated fatty acid
For the health condition: Fatty Liver Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyunsaturated fatty acids (PUFAs), particularly omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been investigated for their role in managing non-alcoholic fatty liver disease (NAFLD). Scientific studies suggest that PUFAs may reduce liver fat accumulation and improve lipid profiles. Mechanistically, omega-3 PUFAs are thought to modulate hepatic gene expression, decrease hepatic lipogenesis, increase fatty acid oxidation, and exert anti-inflammatory effects, which collectively may help reduce hepatic steatosis and slow NAFLD progression.

Clinical evidence is moderate. Meta-analyses and randomized controlled trials have shown that supplementation with omega-3 PUFAs can significantly reduce liver fat content in people with NAFLD, though effects on liver enzymes (ALT, AST) and histological endpoints are inconsistent. For example, a 2016 meta-analysis in Clinical Nutrition found that omega-3 supplementation reduced liver fat but did not significantly improve liver histology. Guidelines from the American Association for the Study of Liver Diseases (AASLD) and European Association for the Study of the Liver (EASL) acknowledge the potential benefit of omega-3 PUFAs for reducing hepatic steatosis, but do not recommend them as standard therapy due to variable results and limited long-term data.

Overall, there is moderate scientific validation for the use of polyunsaturated fatty acids in supporting the management of fatty liver disease, particularly for reducing liver fat, but further research is needed to establish robust clinical recommendations.

More about Polyunsaturated fatty acid
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

Akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
L-glutathione
L-methionine
L-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic compounds
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
Algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
Alpha methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
Camelina Oil
Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fucoidan
Fiber
Fucosterol
Fatty acids
Flavanones
Fucoxanthin
Flavonolignan
Glutathione
Hydroxycinnamic acid
Hydroxytyrosol
Isosilybin
Jaboticaba
Jurubeba
Job's Tears
Kefir
Lycium
Lactobacillus plantarum
Limonoid
Legume protein
Mangiferin
Myricetin
Monounsaturated Fat
Marine fat
Naringenin
Oleuropein
Oolong Tea
Oligosaccharides
Oxymatrine
Ornithine l-aspartic acid
Oleoylethanolamide
Osthole
Phellodendron
Puerarin
Phlorizin
Phaeophyceae
Pinitol
Phlorotannins
Polydatin
Phthalides
Pu-Er Tea
Purple Tea
Punicalagins
Rebaudioside
Rapeseed Oil
Rhubarb
Schizochytrium Oil
Schizochytrium
Silybin
Syringic acid
Salvianolic acid
Salacia
Schisandrins
Silydianin
Silychristin
S-allylcysteine
Sesamin
Sinensetin
Tetradecylthioacetic acid
Tyrosol
Taxifolin
Thistle
Tangeretin
Tanshinone
trehalose
Taurine
Theabrownin
Ursolic Acid
Varuna
Wax Gourd
Wakame
walnut
Yacon
Yin Chen
Zucchini

Products containing Polyunsaturated fatty acid

We currently have no products on Vitabase that contain this ingredient.