Evidence supporting the use of: S-allylcysteine
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

S-allylcysteine (SAC) is a water-soluble organosulfur compound derived from aged garlic extract. Its potential use in supporting or treating fatty liver disease—specifically non-alcoholic fatty liver disease (NAFLD)—is grounded in several preclinical scientific studies, though robust clinical evidence in humans is limited. Animal model research has shown that SAC may exert hepatoprotective effects by reducing oxidative stress, inhibiting lipid peroxidation, and modulating inflammatory pathways, all of which are implicated in the pathogenesis of fatty liver disease. For example, studies in rodents fed high-fat diets have demonstrated that SAC supplementation can lower liver triglyceride levels, decrease liver enzyme markers of injury (such as ALT and AST), and improve histological signs of steatosis and inflammation. These effects are generally attributed to SAC's antioxidant properties and its ability to influence cellular signaling related to fat metabolism and inflammation.

However, there is a lack of high-quality randomized controlled trials in humans examining the efficacy of S-allylcysteine specifically for fatty liver disease. Most available data are from in vitro or animal studies, with only preliminary or indirect evidence in human populations. Therefore, while there is some scientific basis for the potential use of SAC in fatty liver disease, the strength of evidence is modest and further rigorous human studies are needed to confirm efficacy and safety.

More about S-allylcysteine
More about Fatty Liver Disease

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Products containing S-allylcysteine

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