Evidence supporting the use of: Schisandrins
For the health condition: Fatty Liver Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Schisandrins, the bioactive lignans from Schisandra chinensis, have been investigated in several preclinical studies for their potential benefits in treating or supporting fatty liver disease (hepatic steatosis or non-alcoholic fatty liver disease, NAFLD). The scientific rationale is primarily based on animal models and cellular studies. These studies suggest that schisandrins, especially schisandrin B, may exert hepatoprotective effects by reducing liver lipid accumulation, enhancing antioxidant defenses, and modulating inflammatory pathways. Mechanistically, schisandrins appear to influence key regulators of lipid metabolism, such as AMP-activated protein kinase (AMPK), and reduce oxidative stress markers in the liver.

Multiple animal studies (e.g., Zhang et al., 2013, Phytotherapy Research; Pan et al., 2018, Frontiers in Pharmacology) have reported improvements in liver histology and serum biomarkers after schisandrin administration in models of diet-induced fatty liver. However, robust human clinical trials are lacking, and existing evidence in humans is insufficient to make definitive clinical recommendations. The traditional use of Schisandra chinensis in Chinese medicine is primarily for liver protection and strengthening, but the specific use of schisandrins for fatty liver is a more recent, science-driven hypothesis.

In summary, while there is promising preclinical evidence supporting the use of schisandrins for fatty liver disease, high-quality human clinical trials are needed to confirm efficacy and safety. Thus, the evidence rating is moderate (3/5) and based on scientific, not only traditional, foundations.

More about Schisandrins
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
Camelina Oil
Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fiber
Rhubarb
walnut
Zucchini

Products containing Schisandrins

We currently have no products on Vitabase that contain this ingredient.