Evidence supporting the use of: Sulforophane
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sulforaphane, a bioactive compound derived from cruciferous vegetables like broccoli, has been studied in the context of non-alcoholic fatty liver disease (NAFLD), though evidence remains preliminary. Experimental research, mainly in animal models and cell cultures, suggests that sulforaphane exerts protective effects against hepatic steatosis. These effects are attributed to its ability to activate the Nrf2 pathway, reduce oxidative stress, modulate lipid metabolism, and decrease inflammation—key mechanisms implicated in the development and progression of fatty liver disease.

A few small clinical studies have explored sulforaphane's impact on liver function in humans. For example, one randomized controlled trial in patients with NAFLD found that supplementation with broccoli sprout extract (a rich source of sulforaphane) improved certain liver enzymes and reduced oxidative stress markers. However, these studies are limited by small sample sizes, short durations, and variable formulations.

Currently, there is not enough high-quality human evidence to endorse sulforaphane as a definitive treatment or supportive agent for fatty liver disease. The promising preclinical data and limited early clinical trials justify continued research, but its use should be considered experimental rather than established. No traditional use for sulforaphane or broccoli extracts in treating fatty liver disease exists in herbal medicine. Overall, scientific rationale exists, but robust clinical validation is lacking.

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Other ingredients used for Fatty Liver Disease

Akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
L-glutathione
L-methionine
L-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic compounds
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
Algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
Alpha methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
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Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fucoidan
Fiber
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Fucoxanthin
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Glutathione
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Limonoid
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Monounsaturated Fat
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Naringenin
Oleuropein
Oolong Tea
Oligosaccharides
Oxymatrine
Ornithine l-aspartic acid
Oleoylethanolamide
Osthole
Phellodendron
Puerarin
Phlorizin
Phaeophyceae
Pinitol
Phlorotannins
Polydatin
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Pu-Er Tea
Purple Tea
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Rebaudioside
Rapeseed Oil
Rhubarb
Schizochytrium Oil
Schizochytrium
Silybin
Syringic acid
Salvianolic acid
Salacia
Schisandrins
Silydianin
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S-allylcysteine
Sesamin
Sinensetin
Tetradecylthioacetic acid
Tyrosol
Taxifolin
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Tangeretin
Tanshinone
trehalose
Taurine
Theabrownin
Ursolic Acid
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Wakame
walnut
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Yin Chen
Zucchini

Products containing Sulforophane

We currently have no products on Vitabase that contain this ingredient.