Evidence supporting the use of: Tanshinone
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Tanshinone is a class of compounds derived from the roots of Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb. In recent years, there has been growing scientific interest in the potential of tanshinones, particularly Tanshinone IIA, to support or treat fatty liver disease (non-alcoholic fatty liver disease, NAFLD). Preclinical studies in cell culture and animal models have demonstrated that tanshinones can reduce hepatic lipid accumulation, modulate lipid metabolism, and exert anti-inflammatory and antioxidant effects, all of which are relevant to fatty liver disease pathogenesis. For instance, Tanshinone IIA has been shown to activate AMP-activated protein kinase (AMPK) pathways, suppress lipogenesis, and enhance fatty acid oxidation in the liver. Some studies also suggest it may ameliorate insulin resistance and reduce liver fibrosis in NAFLD models. However, to date, high-quality clinical trials in humans are very limited, and most available evidence comes from experimental research and small pilot studies. Thus, while there is a scientific rationale and some supporting laboratory evidence for the use of tanshinones in fatty liver disease, clinical validation remains insufficient. The current rating reflects promising preclinical findings with a need for more robust human data before widespread therapeutic use can be recommended.

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Other ingredients used for Fatty Liver Disease

4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
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Akkermansia muciniphila
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algal oil
Algal protein
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Alpha methyl tetradecylthioacetic acid
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
alpha-lipoic acid
AMP-activated protein kinase (AMPK)
ampelopsin
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anemarrhena asphodeloides
anthocyanins
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apigenin
apocynin
arabinoxylan
argan nut oil
arjun tree
arjuna
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Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
astaxanthin
astragaloside
avocado
baicalein
baicalin
banaba
barberry
barley
beet
berberine
Berberis (unspecified)
betanin
Bifidobacteria
Bifidobacterium bifidum
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bile acid
black garlic
Blakeslea trispora
borotutu
branched-chain amino acids
Brassica
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brutieridin
butyrate triglyceride
butyric acid
camelina oil
carnosic acid
carqueja
catechins
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Caulerpa okamurae
cauliflower
chebulic acid
chia seed
chicory
Chitin-Glucan Complex
chlorella
chlorogenic acid
chokeberry
choline
coix
conjugated linoleic acid (CLA)
copalchi
coriander
corilagin
corosolic acid
crocetin
cruciferous
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cyclodextrin
cynarin
cynaropicrin
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dandelion
danshen
decursin
diallyl disulfide (DADS)
diallyl sulfide
dihydromyricetin
diosgenin
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eicosapentaenoic acid
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EPA (eicosapentaenoic acid)
epicatechin
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ergothioneine
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erythrodiol
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fiber
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l-carnitine
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Products containing Tanshinone

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