Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tetradecylthioacetic acid (TTA) is a synthetic fatty acid analog that has been investigated primarily in preclinical studies for its effects on lipid metabolism and liver health. There is some scientific evidence supporting its potential benefit for non-alcoholic fatty liver disease (NAFLD), mostly from animal studies and limited early-phase human trials. TTA acts as a peroxisome proliferator-activated receptor (PPAR) agonist, particularly activating PPAR-α, which plays a role in fatty acid oxidation and lipid metabolism. In rodent models, TTA supplementation has been shown to reduce hepatic fat accumulation, improve insulin sensitivity, and lower markers of inflammation and fibrosis in the liver. However, clinical evidence in humans is limited. A small randomized controlled trial in patients with type 2 diabetes and NAFLD indicated some reduction in liver fat, but the effect size was modest and not all metabolic parameters improved. TTA is not widely used clinically, and it is not approved as a standard treatment for fatty liver disease. More robust, large-scale human studies are needed to confirm its efficacy and safety. Therefore, while there is scientific rationale and preliminary evidence for TTA's use in fatty liver disease, the overall strength of evidence is low at present.

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Other ingredients used for Fatty Liver Disease

akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
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vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
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morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
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Ampelopsin
Algal protein
Alisma
Arabinoxylan
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Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
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Betanin
Bifidobacteria
bile acid
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chlorogenic acid
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Caulerpa okamurae
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Curcuma
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corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fiber
Fatty acids
Rhubarb
walnut
Zucchini

Other health conditions supported by Tetradecylthioacetic acid

Cholesterol (high)
Fat Metabolism (poor)
Fatty Liver Disease
Metabolic Syndrome
Triglycerides (high)

Products containing Tetradecylthioacetic acid

We currently have no products on Vitabase that contain this ingredient.