Tyrosol is a natural phenolic compound predominantly found in olive oil and certain other plant-based foods. Recent preclinical studies have explored its potential hepatoprotective effects, particularly in the context of non-alcoholic fatty liver disease (NAFLD). Experimental research in animal models suggests that tyrosol may help attenuate hepatic steatosis, oxidative stress, and inflammation—key factors in the development and progression of fatty liver disease. For example, a 2020 study in mice demonstrated that tyrosol supplementation reduced liver fat accumulation, improved antioxidant enzyme activities, and modulated inflammatory markers. These effects are thought to be due to tyrosol’s antioxidant and anti-inflammatory properties, as well as its ability to influence lipid metabolism pathways.

However, evidence in humans is currently lacking. Most available data come from animal studies or in vitro experiments, with very limited clinical data to confirm efficacy or establish appropriate dosing in humans with fatty liver disease. There is also no strong tradition of using tyrosol specifically for liver health in herbal or folk medicine; its potential benefits are a relatively recent scientific discovery tied to broader research on olive polyphenols. Overall, while preliminary scientific evidence supports a possible role for tyrosol in supporting liver health, robust clinical trials are needed before it can be recommended for fatty liver disease.