Evidence supporting the use of: Ursolic Acid
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ursolic acid is a naturally occurring triterpenoid compound found in many plants, such as apple peels, rosemary, and holy basil. Recent scientific studies, primarily in animal models and limited in vitro human cell studies, suggest that ursolic acid may have beneficial effects for fatty liver disease (non-alcoholic fatty liver disease, NAFLD). Its mechanisms of action are thought to include anti-inflammatory, antioxidant, and lipid-lowering effects. For example, several rodent studies have shown that ursolic acid supplementation can reduce hepatic lipid accumulation, improve insulin sensitivity, and decrease markers of liver inflammation and fibrosis. In one notable study (Zhang et al., PLoS One, 2013), mice fed a high-fat diet supplemented with ursolic acid had significantly less hepatic fat and lower levels of liver enzymes indicative of damage.

However, there is a lack of high-quality clinical trials in humans directly evaluating ursolic acid for fatty liver disease. Most evidence is preclinical, and dosing, safety, and efficacy parameters are not well established for human populations. Therefore, while the use of ursolic acid for fatty liver disease is based on scientific rationale and promising preclinical data, it cannot yet be considered an evidence-based therapy, and its overall evidence rating is low to moderate (2/5).

More about Ursolic Acid
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Other ingredients used for Fatty Liver Disease

akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
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Antrodia camphorata
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Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
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Chebulic acid
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chlorogenic acid
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Chitin-Glucan Complex
Caulerpa okamurae
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Curcuma
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Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
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Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
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walnut
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Products containing Ursolic Acid

We currently have no products on Vitabase that contain this ingredient.