Evidence supporting the use of: Vitamin B3 (Niacin)
For the health condition: Fatty Liver Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Vitamin B3 (Niacin) has some scientific basis for its consideration in the management of fatty liver disease, particularly nonalcoholic fatty liver disease (NAFLD), but the evidence is limited and not yet robust. Niacin is known to affect lipid metabolism, primarily by decreasing hepatic synthesis of triglycerides and very-low-density lipoprotein (VLDL). This action is theoretically beneficial for fatty liver, as it could reduce hepatic fat accumulation. Preclinical studies (in vitro and animal models) have shown niacin supplementation reduces hepatic steatosis and inflammation. For example, a 2016 study in mice found that niacin supplementation reduced liver fat content and improved markers of liver inflammation and fibrosis. However, human data are sparse. A small number of clinical studies have explored niacin’s effects on liver enzymes and steatosis in patients with NAFLD or dyslipidemia, but results are mixed and limited by small sample sizes. Moreover, niacin’s use is often limited by side effects such as flushing and potential hepatotoxicity at high doses. Current clinical guidelines do not recommend niacin as a standard therapy for fatty liver disease due to insufficient evidence from large, well-controlled human trials. In summary, while mechanistic rationale and preliminary data exist, robust clinical validation is lacking. The evidence supporting niacin for fatty liver disease is weak to moderate (rated 2 out of 5).
More about Vitamin B3 (Niacin)
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Other ingredients used for Fatty Liver Disease
akkermansia muciniphilaalgal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
Baicalin
Carqueja
Chebulic acid
Camelina Oil
Coriander
chlorogenic acid
Cynarin
Cruciferous
Chitin-Glucan Complex
Caulerpa okamurae
Copalchi
Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fiber
Fatty acids
Rhubarb
walnut
Zucchini
Other health conditions supported by Vitamin B3 (Niacin)
AlcoholismArteriosclerosis
Cholesterol (high)
Circulation (poor)
Fatty Liver Disease
Glaucoma
Migraine
Psoriasis
Schizophrenia
Triglycerides (high)