Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E has been studied as a treatment for nonalcoholic fatty liver disease (NAFLD), especially its more severe form, nonalcoholic steatohepatitis (NASH). The rationale for its use is based on its antioxidant properties: oxidative stress is considered a key factor in the progression of fatty liver disease. Several randomized controlled trials, most notably the PIVENS trial (Sanyal et al., 2010, New England Journal of Medicine), have shown that high-dose vitamin E (800 IU/day) improves liver histology in non-diabetic adults with biopsy-confirmed NASH. Improvements included reduced liver inflammation, steatosis, and ballooning, but not fibrosis.

Based on this evidence, authoritative guidelines such as those from the American Association for the Study of Liver Diseases (AASLD) recommend vitamin E as a first-line therapy for non-diabetic adults with biopsy-proven NASH. However, its use is not recommended for patients with diabetes, cirrhosis, or children, largely due to insufficient safety data and potential risks. Some studies have raised concerns about long-term high-dose vitamin E supplementation, including potential increased risks of prostate cancer and all-cause mortality, though these findings remain debated.

In summary, vitamin E is scientifically validated for certain patients with NASH, with moderate strength of evidence (rated 3/5), but it is not universally recommended for all fatty liver disease cases. Ongoing research will further clarify its role and safety profile.

More about vitamin E
More about Fatty Liver Disease

Other ingredients used for Fatty Liver Disease

Other health conditions supported by vitamin E

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