Evidence supporting the use of: Vitamin E (alpha tocopheryl acetate)
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E (specifically as alpha-tocopherol or its esters like alpha-tocopheryl acetate) has scientific evidence supporting its use in the management of nonalcoholic fatty liver disease (NAFLD), including its more severe form, nonalcoholic steatohepatitis (NASH). Several randomized controlled trials (RCTs) and meta-analyses have evaluated Vitamin E supplementation in adults with NAFLD/NASH, particularly among non-diabetic patients. The most notable is the PIVENS trial (published in the New England Journal of Medicine, 2010), which found that 800 IU/day of Vitamin E improved liver histology in non-diabetic adults with NASH compared to placebo. Improvements were seen in steatosis, inflammation, and ballooning, but not in fibrosis. Subsequent meta-analyses and guidelines (such as those from the American Association for the Study of Liver Diseases) recommend considering Vitamin E therapy in non-diabetic adults with biopsy-proven NASH, although concerns remain about long-term safety and the lack of benefit in diabetic patients or those with advanced fibrosis. The proposed mechanism involves Vitamin E's antioxidant properties, reducing oxidative stress implicated in liver injury. The evidence is moderate in strength, with some limitations in study populations and long-term outcomes. There is no significant historical or traditional use of Vitamin E for fatty liver disease; its use is based on modern clinical research.

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Other ingredients used for Fatty Liver Disease

akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
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algae
AMP-activated protein kinase (AMPK)
ashitaba
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Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
Brown Algae
Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
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Chebulic acid
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chlorogenic acid
Cynarin
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Chitin-Glucan Complex
Caulerpa okamurae
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Curcuma
Corilagin
Crocetin
Cynaropicrin
corosolic acid
Carnosic acid
Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fiber
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walnut
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Products containing Vitamin E (alpha tocopheryl acetate)

We currently have no products on Vitabase that contain this ingredient.