Evidence supporting the use of: Vitamin E (delta-tocotrienol)
For the health condition: Fatty Liver Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, including its tocotrienol forms such as delta-tocotrienol, has been investigated for use in Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) due to its antioxidant properties. Most clinical studies and guidelines focus on alpha-tocopherol, the most common form of Vitamin E, which has shown modest benefit in improving liver histology and reducing markers of liver injury in some patients with NAFLD. The proposed mechanism is reduction of oxidative stress and inflammation in hepatic tissue.

Tocotrienols (including delta-tocotrienol) are less studied than tocopherols but are thought to have even stronger antioxidant and anti-inflammatory properties. Preclinical studies (animal and cell models) suggest tocotrienols may reduce liver fat accumulation, inflammation, and fibrosis. A handful of small human studies and pilot trials have investigated tocotrienol-rich fractions (often containing delta-tocotrienol) in NAFLD, reporting improvements in liver enzymes and some imaging parameters. However, these studies are limited by small sample sizes, short duration, and variability in tocotrienol composition.

Major clinical guidelines (such as AASLD, EASL) recommend Vitamin E (specifically alpha-tocopherol) for non-diabetic adults with biopsy-proven NASH, but do not mention tocotrienols specifically. Thus, while there is a plausible scientific rationale and some early supportive evidence, the overall clinical evidence for delta-tocotrienol in fatty liver disease is limited, and it is not standard of care.

More about Vitamin E (delta-tocotrienol)
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Other ingredients used for Fatty Liver Disease

akkermansia muciniphila
algal oil
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
arjun tree
artichoke
astaxanthin
banaba
barberry
barley
beet
berberine
bifidobacterium bifidum
bifidobacterium longum
black garlic
sesame
branched-chain amino acids
butyrate triglyceride
canola oil
catechins
caterpillar mushroom
cauliflower
chia seed
chicory
chlorella
chokeberry
choline
conjugated linoleic acid (CLA)
turmeric
curcumin
cyclodextrin
dandelion
diallyl disulfide (DADS)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
ginger
grape
hesperetin
kelp
l-carnitine
l-glutathione
l-methionine
l-taurine
lecithin
licorice root
liquid liver fractions
marine lipid
medium chain triglycerides (MCT)
milk thistle
naringin
niacin (vitamin B3)
nicotinamide riboside
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-9 fatty acids
palmitoleic acid
perilla
phenolic acids
phosphatidylcholine
phospholipids
prebiotic blend (proprietary)
butyric acid
psyllium
reishi mushroom
resveratrol
silymarin
spirulina
tocotrienols
trans-pterostilbene
tributyrin
trimethylglycine (TMG)
triphala
Urolithin A
vitamin C
vitamin E
seaweed
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
enicostemma littorale
punarnava
picrorhiza kurroa
lingzhi
morus
ferulic acid
ganoderma
polyphenols
anemarrhena asphodeloides
coix
nopal
algae
AMP-activated protein kinase (AMPK)
ashitaba
4-hydroxyisoleucine
7,14-Hydroxy-Docosapentaenoic Acid
Arjuna
Apigenin
Aronia melanocarpa
Antrodia camphorata
Avocado
Ascophyllum nodosum
Acacetin
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Algal protein
Alisma
Arabinoxylan
Argan nut oil
Anemarrhena
alpha Methyl Tetradecylthioacetic Acid
Apocynin
Arjunolic acid
Borotutu
Brutieridin
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Brassica
Berberis (unspecified)
Baicalein
Blakeslea trispora
Betanin
Bifidobacteria
bile acid
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Coriander
chlorogenic acid
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corosolic acid
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Diallyl sulfide
Danshen
Dihydromyricetin
DL-Methionine
Decursin
D-Pinitol
Diosgenin
Dithiolthiones
epicatechin
Eriocitrin
Ergothioneine
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Fiber
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Rhubarb
walnut
Zucchini

Products containing Vitamin E (delta-tocotrienol)

We currently have no products on Vitabase that contain this ingredient.