Evidence supporting the use of: GABA (gamma aminobutyric acid)
For the health condition: Fear (excessive)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system and plays a critical role in reducing neuronal excitability throughout the nervous system. Its function is closely associated with the regulation of anxiety, fear, and stress-related responses. Scientific research has demonstrated that GABAergic signaling is disrupted in various anxiety disorders and that pharmacological agents that enhance GABA activity (such as benzodiazepines) are effective for the acute management of anxiety and fear. However, the use of supplemental GABA itself as a treatment for excessive fear is less well established in humans, primarily due to questions about its ability to cross the blood-brain barrier when taken orally. Some small clinical studies and anecdotal reports suggest that oral GABA supplements may have calming effects, potentially reducing the perception of acute stress or fear. However, these studies are limited in size and scope, and many reviews conclude that the scientific evidence for the effectiveness of oral GABA supplements in treating excessive fear or anxiety is weak. Most of the robust evidence supporting the role of GABA in fear reduction comes from pharmacological interventions that act on GABA receptors, not from direct GABA supplementation. In summary, while the theoretical and pharmacological basis for targeting the GABAergic system in fear and anxiety is strong, direct evidence for the use of supplemental GABA to treat excessive fear in humans is limited and only weakly supported by current scientific research.

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