Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Active Hexose Correlated Compound (AHCC) is a proprietary extract derived from the mycelia of shiitake mushrooms and other species of Basidiomycetes. Its use to support the female reproductive system, particularly for immune modulation related to persistent high-risk human papillomavirus (HPV) infections, is based on emerging scientific evidence. Several clinical studies and pilot trials have investigated AHCC’s potential to enhance immune responses in women with persistent HPV infections, which are associated with the development of cervical dysplasia and cervical cancer.

One notable randomized, double-blind, placebo-controlled study published in 2019 (Smith et al., Frontiers in Oncology) found that daily supplementation with AHCC for up to 6 months led to a significantly higher rate of HPV clearance compared to placebo. The proposed mechanism involves AHCC’s ability to modulate immune parameters, including increased interferon-gamma and natural killer cell activity, which may help the body clear HPV infections more effectively. Additional in vitro and animal studies support these immunomodulatory effects.

While these results are promising, the number of high-quality, large-scale clinical trials remains limited. AHCC is not traditionally used for female reproductive health—its application in this area is a recent development based on scientific investigation rather than historical or traditional use. Thus, the evidence base is moderate but growing, and more robust clinical trials are needed to fully establish efficacy and optimal dosing protocols in the context of female reproductive system health.

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Other ingredients that support Female Reproductive System

25-d-spirosta-3, 5-diene
27-deoxyactein
7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abuta
Agnuside
AHCC
Alchemilla
Aletris
amino acids
anamu
anemarrhena asphodeloides
Anemone
Angelica
animal protein
anise
Anserina
Ashoka
ashwagandha
barbasco
basil
Belamcanda
bethroot
betony
bird\'s nest
black cohosh
blessed thistle
blue cohosh
borage oil
broccoli
bugbane
Caesalpinia crista
Calochortus
casticin
Ceylon leadwort
chaste tree
Chinese pond turtle
Chlorophytum
Clary sage
Cnidium
cohosh
cramp bark
Crinum latifolium
Cynomorium
d-alpha tocopherol
daidzein
damiana
dandelion
date
DHEA
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dioscorea
diosgenin
dodder
dong quai
dong quai root
egg
eleuthero
equol (proprietary)
Erythrina
estrogen
evening primrose oil
evening primrose oil
false unicorn root
fatty acids
fennel
fenugreek
flaxseed
fo-ti
folate
folic acid
formononetin
furostanols
gamma linolenic acid (GLA)
genistein
giant trillium
ginger
Ginsenosides
goat\'s rue
golden ragwort
goldenseal
guelder rose
herbal blend (proprietary)
hibiscus
HMR lignan
horny goat weed
Hypericum
Indian fagonia
Indian tinospora
indole-3-carbinol
inositol
inositol phosphate
isoflavones
jasmine
jujube
Kigelia africana
Labisia pumila
labrador tea
Lactobacillus acidophilus
Lactobacillus crispatus
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus jensenii
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lady's Mantle
Laminaria
Leptadenia
lignans
ligustilides
lingzhi
linoleic acid (LA)
lipids
Loranthus
maca
macaenes
macamides
mandrake
Marine lipid
Miroestrol
Montanoa tomentosa
Motherwort
Mugwort
Nettle
Nigella seed
omega-3 fatty acids
Pennyroyal
peony
Phytoestrogens
polyunsaturated fat
Puerain
Pulsatilla
raspberry
red clover
rose
rose oil
royal jelly
Rubia cordifolia
Rubus
rue
Safed musli
saffron
selenium
Shataverins
shepherd's purse
Sichuan Lovage
Soy
soy isoflavones
Soy Protein
soybean
Sparganium
spearmint leaf
squawvine
Szechuan lovage
Taxillus chinensis
trace minerals
tribulus
turmeric
Vervain
Viburnum
vitamin B
vitamin B6
vitamin E
Vitex Agnus-Castus
Vitexicarpin
White Dead Nettle Flower
Wild yam
Wood betony
Yarrow
Yarrow

Other body systems supported by AHCC

Female Reproductive System
Gastrointestinal Tract
Hepatic System
Immune System
Intestinal System
Lymphatics

Products containing AHCC

We currently have no products on Vitabase that contain this ingredient.