Evidence supporting the use of: Diindolylymethane
For the body system: Female Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. Its use in supporting the female reproductive system, particularly in relation to estrogen metabolism and hormonal balance, has a foundation in scientific research, though most studies are preliminary or conducted in vitro or in animals, with some small human trials.

DIM is thought to modulate estrogen metabolism by favoring the production of less potent estrogen metabolites, such as 2-hydroxyestrone, over more potent forms like 16α-hydroxyestrone. This activity is theorized to help maintain a healthier balance of estrogens in the body, which could be beneficial in hormone-related conditions such as premenstrual syndrome (PMS), fibroids, and possibly in reducing the risk of estrogen-sensitive cancers. Some small clinical studies have shown that DIM supplementation can alter urinary estrogen metabolites in women, supporting the mechanism, but clinical benefits for specific reproductive conditions are less well established.

Overall, while there is a plausible biological rationale and some early evidence supporting DIM’s effects on estrogen metabolism, robust, large-scale clinical trials demonstrating clear benefits for specific female reproductive system conditions are lacking. Therefore, the use of DIM for this purpose is scientifically plausible and somewhat validated, but evidence strength remains moderate.

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Other ingredients that support Female Reproductive System

7-hydroxymatairesinol (HMR)
amino acids
ashwagandha
basil
black cohosh
borage oil
broccoli
chaste tree
turmeric
d-alpha tocopherol
damiana
dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
eleuthero
evening primrose oil
fennel
fenugreek
flaxseed
folate
gamma linolenic acid (GLA)
genistein
ginger
goldenseal
hibiscus
HMR lignan
Indian tinospora
indole-3-carbinol
inositol
jujube
lactobacillus acidophilus
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus jensenii
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lignans
linoleic acid (LA)
maca
marine lipid
motherwort
nettle
omega-3 fatty acids
raspberry
rose oil
saffron
selenium
soybean
spearmint leaf
tribulus
vitamin B
vitamin B6
vitamin E
wild yam
red clover
squawvine
mugwort
anise
caesalpinia crista
rubia cordifolia
blessed thistle
peony
lingzhi
lingusticum wallichii
yarrow
yarrow
dioscorea
dodder
royal jelly
Equol (proprietary)
guelder rose
trace minerals
anemarrhena asphodeloides
shepherd's purse
wood betony
herbal blend (proprietary)
soy isoflavones
27-deoxyactein
25-d-spirosta-3, 5-diene
8-Prenylnaringenin
Angelica
Anamu
AHCC
Alchemilla
Aletris
Anserina
Anemone
Agnuside
Ashoka
Abuta
Animal protein
Betony
Blue Cohosh
Bugbane
Bethroot
Barbasco
Belamcanda
Bird's nest
Calochortus
Cohosh
Clary sage
Cnidium
Cynomorium
Cramp Bark
Chinese Pond Turtle
Chlorophytum
Casticin
Ceylon Leadwort
Crinum latifolium
DHEA
Daidzein
Dong Quai
Diosgenin
Date
Egg
Erythrina
Evening Primrose Oil
Estrogen
Folic Acid
False Unicorn Root
Isoflavones
jasmine
Pennyroyal
Rose
Soy Protein
Vervain

Products containing Diindolylymethane

We currently have no products on Vitabase that contain this ingredient.