Evidence supporting the use of: Diindoylmethane
For the body system: Female Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Diindolylmethane (DIM) is a compound formed in the body during the digestion of indole-3-carbinol, which is found in cruciferous vegetables such as broccoli and Brussels sprouts. DIM has garnered scientific interest for its potential effects on estrogen metabolism. Specifically, DIM is thought to promote the production of beneficial estrogen metabolites that may support hormonal balance in women. Several in vitro and animal studies, as well as a limited number of small human trials, suggest that DIM may modulate estrogen pathways, potentially influencing conditions such as premenstrual syndrome (PMS), cyclical breast pain, and even symptoms related to menopause. However, while these mechanisms are promising, clinical studies in humans are still relatively few and often involve small sample sizes or lack rigorous controls. There is some preliminary evidence that DIM supplementation can alter urinary estrogen metabolite ratios, which has been interpreted as beneficial for hormone-related health. Nevertheless, definitive conclusions about its efficacy for broad "female reproductive system support" or for specific conditions such as fibroids, endometriosis, or fertility are not yet supported by robust clinical evidence. Therefore, while the use of DIM is based on plausible biochemical mechanisms and early research findings, the overall evidence base is moderate and further well-designed human studies are necessary to fully validate its use for this purpose.

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Other ingredients that support Female Reproductive System

7-hydroxymatairesinol (HMR)
amino acids
ashwagandha
basil
black cohosh
borage oil
broccoli
chaste tree
turmeric
d-alpha tocopherol
damiana
dandelion
DHEA (dehydroepiandrosterone)
DIM (diindolylmethane)
dong quai root
eleuthero
evening primrose oil
fennel
fenugreek
flaxseed
folate
gamma linolenic acid (GLA)
genistein
ginger
goldenseal
hibiscus
HMR lignan
Indian tinospora
indole-3-carbinol
inositol
jujube
lactobacillus acidophilus
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus jensenii
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lignans
linoleic acid (LA)
maca
marine lipid
motherwort
nettle
omega-3 fatty acids
raspberry
rose oil
saffron
selenium
soybean
spearmint leaf
tribulus
vitamin B
vitamin B6
vitamin E
wild yam
red clover
squawvine
mugwort
anise
caesalpinia crista
rubia cordifolia
blessed thistle
peony
lingzhi
lingusticum wallichii
yarrow
yarrow
dioscorea
dodder
royal jelly
Equol (proprietary)
guelder rose
trace minerals
anemarrhena asphodeloides
shepherd's purse
wood betony
herbal blend (proprietary)
soy isoflavones
27-deoxyactein
25-d-spirosta-3, 5-diene
8-Prenylnaringenin
Angelica
Anamu
AHCC
Alchemilla
Aletris
Anserina
Anemone
Agnuside
Ashoka
Abuta
Animal protein
Betony
Blue Cohosh
Bugbane
Bethroot
Barbasco
Belamcanda
Bird's nest
Calochortus
Cohosh
Clary sage
Cnidium
Cynomorium
Cramp Bark
Chinese Pond Turtle
Chlorophytum
Casticin
Ceylon Leadwort
Crinum latifolium
DHEA
Daidzein
Dong Quai
Diosgenin
Date
Egg
Erythrina
Evening Primrose Oil
Estrogen
Folic Acid
False Unicorn Root
Isoflavones
jasmine
Pennyroyal
Rose
Soy Protein
Vervain

Products containing Diindoylmethane

We currently have no products on Vitabase that contain this ingredient.