Vitamin E, particularly as mixed tocopherols including alpha-tocopherol, has some scientific evidence supporting its role in the female reproductive system, though the evidence is limited and not robust. Vitamin E is a fat-soluble antioxidant that protects cell membranes from oxidative stress, which is relevant because oxidative damage can impact reproductive tissues and processes. Small clinical trials and observational studies have suggested that vitamin E supplementation may improve endometrial response in women undergoing fertility treatments, reduce symptoms of premenstrual syndrome (PMS), and potentially improve menstrual regularity in women with certain reproductive disorders (such as polycystic ovary syndrome).

For example, a few studies have found that vitamin E supplementation improved endometrial thickness and pregnancy rates in women undergoing assisted reproductive technologies (ART). Other research has shown a reduction in dysmenorrhea (painful periods) and PMS symptoms with vitamin E supplementation, likely due to its anti-inflammatory and antioxidant effects. However, most of these studies are small, have methodological limitations, or show only modest benefits.

Overall, while there is some scientific basis for the use of vitamin E in supporting female reproductive health, the evidence is not strong enough to recommend it as a primary intervention for most reproductive issues. More rigorous and large-scale studies are needed to clarify its effectiveness and safety in this context.