Evidence supporting the use of: Andrographolide
For the health condition: Fever

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Andrographolide, the main bioactive compound in Andrographis paniculata, has been traditionally used in various Asian systems of medicine to treat fever and related infections. In recent years, scientific studies have investigated its potential antipyretic (fever-reducing) effects. Several preclinical studies have demonstrated that andrographolide and extracts of Andrographis paniculata can reduce elevated body temperatures in animal models, likely by modulating inflammatory mediators such as prostaglandins and cytokines. For example, research published in Phytomedicine (2010) and other journals found that the compound has significant anti-inflammatory and antipyretic effects, possibly via inhibition of the NF-κB pathway and suppression of pro-inflammatory cytokines (such as TNF-α and IL-6). Clinical evidence in humans is more limited, but some randomized controlled trials have shown that Andrographis paniculata extracts can help reduce fever in the context of upper respiratory tract infections and uncomplicated common colds. However, these effects are often reported as part of broader symptom relief, and results across studies are not entirely consistent. The antipyretic effect is generally considered moderate and is often secondary to its anti-inflammatory or immune-modulating actions. Overall, while there is both a traditional basis and some scientific evidence supporting the use of andrographolide for fever, the clinical data are not robust enough to warrant a higher rating. More well-designed human studies are needed to confirm its efficacy and safety for this specific indication.

More about Andrographolide
More about Fever

Other ingredients used for Fever

allspice
aloe vera
green chiretta
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barberry
basil
myrobalan
betel
black cumin
black pepper
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blackberry
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bupleurum falcatum
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cassia bark
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cinnamon
citrus sinensis (proprietary)
coconut milk
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cucumber
turmeric
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feverfew
forsythia
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glehnia root
goldenseal
gooseberry
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onion
heartwood
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honeysuckle
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jujube
kudzu
lemon
licorice root
lophatherum leaf
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lychee
mangosteen
milk
moringa
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nettle
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oregano
oregon grape
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rosemary
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Barleria
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Products containing Andrographolide

We currently have no products on Vitabase that contain this ingredient.