Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Trichosanthes, particularly the root (commonly known as Trichosanthes kirilowii or "Tian Hua Fen" in Traditional Chinese Medicine), has a long history of use in traditional medicine systems such as Traditional Chinese Medicine (TCM) and Ayurveda. In TCM, Trichosanthes root is utilized for its purported "heat-clearing" and "detoxifying" properties, and it is often included in formulations intended to reduce fever and treat febrile illnesses, especially those believed to be caused by "internal heat" or "toxic heat". Historical texts, such as the "Shennong Bencao Jing" and later materia medica, describe its use for fever, thirst, and related symptoms. The evidence rating is 2, reflecting that while there is robust traditional use and some preliminary pharmacological studies suggest anti-inflammatory effects, there is a lack of high-quality clinical trials in humans specifically confirming its effectiveness for fever reduction. Some laboratory studies have found that extracts of Trichosanthes possess anti-inflammatory and immunomodulatory activities, which could theoretically contribute to fever reduction, but these findings are not sufficient to establish scientific validation by modern standards. In summary, Trichosanthes is primarily used to support or treat fever based on tradition, particularly within Asian herbal medicine, but modern scientific evidence supporting its efficacy for this specific indication is limited and not definitive.

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