Evidence supporting the use of: Diindolylymethane
For the health condition: Fibroids (uterine)
Synopsis
Source of validity: Scientific
Rating (out of 5): 1
Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables like broccoli and cabbage. Its use for uterine fibroids is based on its ability to influence estrogen metabolism, shifting it toward the production of less potent estrogen metabolites. Since fibroids are considered estrogen-sensitive tumors, the rationale is that DIM might reduce their growth or symptoms by altering estrogen activity in the body.
However, scientific evidence supporting DIM for uterine fibroids is very limited. The majority of the available data comes from laboratory studies or animal models rather than human clinical trials. Some in vitro studies suggest that DIM can modulate estrogen pathways and possibly reduce the proliferation of certain hormone-dependent cells, but no robust randomized controlled trials have evaluated its safety or efficacy specifically for fibroids in women.
A small number of preliminary or pilot human studies have explored DIM’s effects on other estrogen-related conditions (like cervical dysplasia or prostate health), but not directly on fibroids. Therefore, while the theoretical basis exists, clinical validation is lacking, and its use for fibroids cannot be considered evidence-based at this time.
In summary, while there is a scientific rationale for investigating DIM in the context of fibroids, the actual supporting evidence is minimal (rated 1 out of 5), and more research is needed before it can be recommended for this purpose.
Other health conditions supported by Diindolylymethane
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Fibroids (uterine)
Inflammation
Liver Detoxification
Menopause
PMS (general)